Midfielder Kari Arnason is available again following suspension as Aberdeen head to Dumfries.
Strikers Michael Paton and Daniel Uchechi could return, easing the Dons' lengthy injury list, but Clark Robertson is out after twisting his knee in Saturday's goalless draw at Hibernian.
Defender Russell Anderson, midfielders Rob Milsom, Isaac Osbourne, Yoann Folly, Gavin Rae, Chris Clark and Peter Pawlett are all out injured.
The winners will be away to Motherwell in the quarter-finals on the weekend of March 10/11.
Aberdeen (from): Brown, Considine, McArdle, Reynolds, Arnason, Jack, Fyvie, Vernon, Megginson, Chalali, Fallon, Langfield, Magennis, Mackie, Hughes, Mawene, Paton, Uchechi.