Gareth Bale has recovered from illness and looks set to start for Spurs.
Spurs will field a relatively strong side, which is likely to include Scott Parker, who is back from suspension, while William Gallas could feature after missing the last two months with a calf injury.
Ledley King will be rested, Rafael van der Vaart is a doubt with a calf injury, and Tom Huddlestone (ankle) is out.
Chris Beardsley is a doubt for Stevenage. Boro's leading scorer missed the 1-1 draw at Exeter over the weekend after suffering a hamstring injury against Charlton on February 25.
Should the striker fail to recover in time, Blackburn loanee Jordan Slew is likely to continue to lead the line alongside Craig Reid after making his debut against the Grecians.
Jon Ashton shook off a head injury to play the full 90 minutes at St James Park and he is expected to resume his role in the heart of defence.
Spurs (from): Friedel, Gomes, Cudicini, Assou-Ekotto, Rose, Kaboul, Gallas, Khumalo, Walker, Smith, King, Dawson, Nelsen, Livermore, Sandro, Parker, Bale, Kranjcar, Lennon, Dos Santos, Modric, Defoe, Adebayor, Saha, Van der Vaart, Lancaster, Luongo.