Crawley are set to welcome back Kyle McFadzean and Claude Davis.
McFadzean and Davis were among the players punished for their part in the post-match brawl that marred last month's 2-1 win at Bradford.
The defensive duo served the final game of their suspensions when the Red Devils drew 1-1 with AFC Wimbledon on Saturday, although Pablo Mills is still banned.
Caretaker manager Craig Brewster has further disciplinary problems to contend with as midfielder Hope Akpan received a straight red card in the opening stages against the Dons, while Sergio Torres will serve the second game of a three-match ban for his dismissal against Barnet on Easter Monday.
Charlie Wassmer is expected to retain his place at centre-back having been handed only his second start of 2012 at the weekend, but the game comes too soon for David Hunt (broken foot) despite the right-back returning to light training.
Crawley, who are certain of an League Two play-off place, will move back into the automatic promotion places on goal difference if they beat Aidy Boothroyd's side.
Ben Harding remains an injury doubt for Northampton ahead of their trip.
Harding missed the home defeat to Bradford on Saturday and Cobblers boss Aidy Boothroyd believes the away game at Hereford at the weekend is a more likely target for the midfielder's return.
"Ben has got a little bit of Achilles tendon trouble," said Boothroyd. "It's nothing too serious but with the grounds getting a little bit harder now and with the amount of games he's played in a short space of time the last thing I want to do is give him a problem.
"He will be doubtful for Crawley - we're going to give him a fitness test but we are more looking for Saturday's game."
Boothroyd added: "We came through Saturday's game okay, we picked up the usual bumps and bruises but nothing that is too serious."
Defender Byron Webster and attackers Lewis Young, Jake Robinson and Lewis Wilson are among the options for Boothroyd should he wish to make changes.