Ryan Dickson returns from suspension for Orient.
The defender, on loan from Southampton, picked up two yellow cards in the 1-0 win over Oldham.
Scott Cuthbert picked up a hamstring injury in Saturday's 2-0 defeat to Charlton and looks set for a prolonged spell on the sidelines.
Manager Russell Slade told the club website: "He's just on crutches now so it's quite alarming really how many injuries to defenders we've picked up in games recently."
Jamal Campbell-Ryce is a doubt after missing the last two matches with an ankle knock.
But Lee Butcher (knee) and Jamie Jones (wrist) could return after missing Saturday's match.
Huddersfield defender Calum Woods is hoping to return to contention at Brisbane Road.
Woods missed the weekend defeat at Carlisle after the recurrence of a slight groin problem, but returned to full training on Monday and could be included in manager Simon Grayson's plans.
The Terriers slipped eight points adrift of the top two after going down to a stoppage-time winner at Carlisle on Saturday, so will be anxious to take maximum points from their game in hand.
Grayson has no new injury or suspension worries, but will still be without left-back Gary Naysmith (knee) and midfield duo Oscar Gobern and Damien Johnson (both hamstring).
Midfielders Scott Arfield and Joey Gudjonsson, striker Alan Lee and defender Jamie McCombe are all pushing for recalls as Town chase a seventh league win on the road this season.