Thanks for joining me today, stay with us for a full match report and all the post-match reaction.
Roberto Mancini's men are now three points clear of United, who still have to play Swansea later today. City know victory over QPR at home next Sunday will secure their first top-flight crown since 1968.
Webb blows the final whistle! Man City have one hand on the Premier League trophy thanks to two goals from Yaya Toure.
Aguero looks to get away again but is denied by Gutierrez and Coloccini.
Another good save from Hart as he is in the right place at the right time to pluck Ameobi's shot out of the air.
Three additional minutes will be played.
Good save from Hart to deny Ba.
89 City break from a Newcastle corner through Aguero. He holds the ball up and then feeds De Jong, who passes it on to Clichy on the left of the box. He takes his time and finds Toure, who passes it over Krul from close range.
89 GOAL FOR MAN CITY!!!! Toure again!
Superb block from Richards to get in the way of Ameobi's goalbound shot from the edge of the area.
Aguero fires a cross into the box towards Dzeko, but Ameobi is back to help out his defence and gets in a crucial block.
Nerves jangling in the City box as Gutierrez's cross is headed back across the face by Ba but Ameobi cannot get to the ball.
86 City make their final switch as David Silva makes way for Micah Richards.
Narrowly wide from the corner as Dzeko gets to the ball first but puts it past the near post.
CITY GO CLOSE AGAIN!!! Aguero plays Toure clean through, but he slips at the vital moment as he rounds Krul, with Aguero's follow up then tipped over by the goalkeeper.
82 Newcastle's final change with Ryan Taylor on for Tiote.
Silva swings over a free-kick from out on the right flank and Toure glances his header narrowly wide.
80 Now Ferguson is booked for a late challenge on Silva. The clearance went to Aguero, who wanted an advantage played as he was clear.
79 Zabaleta booked after clattering into Ferguson. Cynical from the City man who had been beaten all ends up.
Newcastle go close, with Cisse heading narrowly wide of the target after good play from Ameobi.
Barry heads clear before Kompany reads the danger well as Newcastle go back on the attack to slide the ball out for a throw.
Ferguson earns a corner for Newcastle.
Replay of the Aguero chance shows he missed the post by all of an inch. Still should have scored.
HUGE MISS FOR MAN CITY!!! Aguero is through on goal after Silva's stunning pass but he rolls his shot the wrong side of the post.
74 Double change for Newcastle. Shane Ferguson and Shola Ameobi on for Hatem Ben Arfa and James Perch.
Big chance for Dzeko to make it 2-0. He brings down a superb cross-field pass before blazing hopelessly wide.
Barry is down after a challenge from Cisse, with the striker standing on the midfielder's arm as he lies on the floor. Looked accidental.
De Jong was also involved in the build up to that goal and his presence on the field has allowed Toure to push further forward. I'll leave Mancini to it.
70 Superb finish from Yaya Toure as he bends a brilliant shot around Tim Krul and into the bottom corner after playing a one-two with Aguero.
70 GOAL FOR MAN CITY!!!!
70 Another change from City, with Dzeko on for Tevez.
Clichy looks to break down the left, but the ball runs out.
Zabaleta is found in space on the right of the Newcastle box, but his attempted cross-shot is way off target.
Good footwork from Ba to work some space out on the left of the area, but his shot is blocked by Lescott.
Silva's initial corner is cleared and his second cross brings a free-kick as Lescott challenges Krul.
Tevez earns a corner as Coloccini heads behind.
Great skill from Ben Arfa to make a yard of space in the City box before lashing his shot high and wide.
Silva tries to wriggle through the eye of the needle on the edge of the Newcastle box, but Coloccini brings the ball away.
It's fair to say De Jong is not too popular on Tyneside, with the fans remembering his challenge which left Hatem Ben Arfa with a broken leg last season.
62 Strange change from City, with midfield enforcer Nigel De Jong coming on for Samir Nasri.
Toure's ball over the top towards Tevez is too long and goes out for a goalkick.
Ben Arfa leaves Toure on his backside, before beating himself and allowing the ball to run out for a goalkick.
Great skill from Ba on halfway to pull the ball out of the air before a few kick-ups. But he then spoils it by giving the ball away.
Gutierrez is penalised for holding back Aguero in midfield.
Tevez lines up a shot from range which goes straight at Krul.
After a rather ugly passage of play, Tevez eventually curls well wide as Newcastle struggle to clear their lines. Toure is holding his arm, but should be OK to continue.
Clichy earns a corner after playing the ball against Perch.
Toure tries to bend the ball over the wall and into the top corner but only succeeds in firing it over the top.
Free-kick for City on the edge of the Newcastle box as Perch is penalised for his challenge on Tevez.
Kompany brings the ball out of defence, but his pass forward is hopeful rather than precise and Krul claims.
Scoreline of interest to Newcastle fans: Villa have gone 1-0 up against Tottenham.
First attack from Newcastle sees Cisse's attempted cross headed away by Lescott before Clichy completes the clearance.
No changes from either manager at the interval.
City get us under way in the second period.
Joe Hart and his Man City team-mates are out for the second period, with Newcastle not far behind. Huge 45 minutes coming up.
There have been chances at both ends, with Hart alert to parry Ben Arfa's volley, while Barry saw his follow-up shot cleared off the line by Santon after Coloccini had blocked the initial effort.
45+2 Webb brings an entertaining half to a close.
One additional minute will be played.
Ben Arfa looks to go around Clichy, but the defender has just as much pace as his compatriot.
Kompany goes to ground after a tangle with Ba. The Magpies man apologises and the big defender is soon back on his feet.
Nasri is penalised for handball in the box after Aguero's cross. Great defending by the Magpies just now to deny Barry. Superb stuff.
SO CLOSE FOR CITY!!! Double clearance to deny Barry, with first Krul and Coloccini blocking the midfielder's effort from Silva's pull-back, before Santon kicks it off the line after another shot by the England man.
Ba heads over the bar from Ben Arfa's excellent cross following good work from Gutierrez down the left.
Gutierrez tries to shoot first-time from the edge of the area, but Nasri is back to block.
38 Toure goes into the book for bringing down Santon.
City go back on the attack, with Toure finding Zabaleta out on the right. His low pull back rolls all the way across the area after Coloccini slips, but there are no blue shirts in the right place to take advantage.
36 Perch goes into the book for a nibble on the back of Tevez's heels.
Cabaye's clever ball into the box is just too long for Cisse with Hart racing out to gather.
NEWCASTLE GO SO CLOSE!!! Superb save from Hart to deny Ben Arfa after Ba's initial shot was blocked by Clichy following excellent work from Gutierrez.
Chance wasted by Man City as Silva clips it in but no-one is alert to his intentions and the ball goes behind for a goalkick.
32 Tiote brings down Silva 10 yards outside the Newcastle area. Webb initially attempts to play the advantage before bringing play back and booking the Newcastle man.
Now it's Krul's turn to blunder as his poor clearance goes straight to Nasri with the keeper way out of position. The Frenchman tries his luck, but the ball hits Toure and the chance is gone.
Cabaye's ambitious attempt from around 35 yards is blocked by the wall, with Tiote's follow up also charged down by the City defence.
30 Barry booked for a cynical pull on Cabaye after Hart's poor kick puts City back under immediate pressure.
Quick break from Newcastle as Ben Arfa pinches the ball back from Clichy. He finds Ba on the edge of the area, with his powerful shot on the turn only narrowly over Hart's bar.
Bit of push and shove between Nasri and Cisse in the wall, before Tevez curls a shot towards goal which Krul is able to gather with relative ease.
26 Clichy steals the ball from Ben Arfa, with the Magpies midfielder booked after conceding a free-kick in a dangerous position.
Good work from Krul, showing excellent awareness to claim the ball ahead of Silva after clever play between Tevez and the Spaniard.
Clichy crosses from the left towards Aguero, who cannot bring the ball under his spell and it bounces out for a goalkick.
Nice play from Cabaye in midfield to find Cisse, but the striker's attempted return pass is too strong and City clear.
Newcastle are almost caught out by a long ball out of defence from Kompany. Krul rushes from his line but is beaten to the ball outside the box on the right by Aguero, but his attempted cross is smuggled away for a corner, which comes to nothing.
Zabaleta escapes down the right again and fires a quick cross into the box, which Williamson clears.
In the last 10 minutes, City have enjoyed 77 per cent of the possession. Need to make it count, though.
Another decent save from Krul, as Silva's pass finds Aguero on the left of the area. He checks inside and hits a low shot, which lacks power, and Krul drops on it.
Aguero gives the ball away to Ben Arfa, who slides an excellent pass through to Demba Ba, but the striker's control lets him down and he turns away in disappointment.
City begin to build another attack from the back, with Lescott, Kompany and Zabaleta all involved.
All the possession is with City at the moment and they have Newcastle pinned back in their own half.
Tevez, who is looking busy this afternoon, attempts to find Nasri in the box, but Coloccini is across to clear his lines.
Newcastle break and Cisse finds Ba, but the striker is blocked by the imposing figure of Vincent Kompany.
Good save from Krul! Nasri and Silva combina again with the Spain international's low shot palmed away by the Magpies keeper.
Newcastle switch off and Nasri's short corner finds Silva, whose shot is blocked for another corner, which Newcastle clear through Tiote.
More good play from City with Tevez feeding Nasri down the left. His initial shot is blocked as is Toure's follow-up. City keep pressing and win a corner.
City knocking the ball around nicely in midfield, before Tevez's attempted ball to Zabaleta down the right channel is just overhit. Better from the visitors.
Barry goes down holding his face after ducking in to a challenge with Cabaye, with the Magpies man immediately apologising.
Ba attempts to flick the ball on towards Cisse, but gets too much on it and Hart is able to gather easily.
Long ball forward to Ba out of defence, but Lescott stands up well against the striker and clears his lines.
Couple of passes going astray in the first few minutes as there is obviously tension among both teams.
Early touch for Joe Hart as he comfortably gathers Tiote's ball into the box.
Tiote is immediately battling away in midfield and wins a free-kick after a challenge from Tevez.
Newcastle get the game under way.
A wall of noise greets the players as they make their way out onto the pitch for the pre-match formalities and handshakes.
Both teams are in the tunnel and almost ready to make their way out onto the field. Few nervous glances and smiles from players on both sides.
St James' Park is filling up nicely with kick-off just five minutes away now...
Slight concern for Newcastle pre-kick-off with Tim Krul having his hand checked after punching clear in the warm-up. Looks like he will be OK, though.
Top Twitter name @homewiththewife says: "Everyone is saying hard game for man city but not me 4-1 to city."
Both teams are, perhaps unsurprisingly, unchanged after vital victories last time out. But Mario Balotelli is conspicuous by his absence from the Manchester City bench.
Jeff from Chongqing in China reckons: "A very strong looking line up N'cle have, and I just cant see anything other than a Toon win....howay the lads."
Adam Taylor says: "As a Spurs fan I desperately want Man City to win but Newcastle are a great side! 2-2."
Edd Irwin writes: "Ex-Magpies supporter in the 1950's. Now living in Durban,South Africa. I've been watching Castle all season and they've done very well.I predict a 1-0 win for the Magpies."
Right, prediction time. Having tipped Fulham to win at Anfield on Tuesday night, I'm on a roll. Sort of. I reckon the title race could get blown wide open again this afternoon, with a scoring draw on the cards. 2-2.
Scott (confidently) writes: "Man City will get just the one goal today from Aguero. 3-1 home win to Newcastle. Coupled with the fact that Arsenal dropped vital points and I think Spurs will lose today, Newcastle will sit pretty in 3rd."
Just 30 minutes to go until kick-off at St James' Park. The tension is building.
Getting plenty of feedback from Man Utd fans this afternoon, can't think why they're so interested in this game....
Opta stat No.4: Papiss Cisse has scored 13 goals in his 12 top-flight appearances, the joint-best start to a player's Premier Leaugue career.
Opta stat No.3: City have won their last four games in a row and are looking to win five in a row for the first time since a spell of seven successive wins in September/November.
Opta stat No.2: Newcastle have won seven of their last eight games and have netted the highest proportion of first half goals in the top flight this season (51%).
Opta stat No.1: City have scored at least two goals in each of their last seven Premier League games against Newcastle.
Couple of stats from the nice people at Opta prior to kick-off.
Roberto Mancini has spent most of the week claiming this game will be tougher than the derby on Monday. Given the form Newcastle are in at the moment - Wigan aside - you can almost see where he's coming from.
Man City subs: Pantilimon, Johnson, Kolarov, Dzeko, Milner, Richards, De Jong.
Charlie Collier, a Man Utd fan in Bangkok, writes: "If Newcastle win then obviously I am happy but in a way I also feel that if City go on to win the title then at least United would have to seriously strengthen their squad for next season which can only be a good thing. Whoever wins the Premier League they deserve it."
@mattyrayson says: "I think we (#NUFC) have a good chance of winning today... now that we have a statue of Sir Bobby looking over us..."
Newcastle fan Kieran Palmer says: "This will be a very tough game as Newcastle will give it their all to try for the Champions League and for Man City this is an important game as they push for the title. My prediction is a 2-2 draw."
Adam Gillis writes: "Newcastle will be fired up for this game just as much as we are. I expect a calm and classy performance so I'm going 3-1 City."
Howard Webb is the referee for this afternoon's vital showdown.
Newcastle subs: Elliot, Ferguson, R Taylor, Gosling, Marveaux, Obertan, Ameobi.
Man City: Hart, Zabaleta, Clichy, Kompany, Lescott, Barry, Yaya, Nasri, Silva, Aguero, Tevez.
Newcastle: Krul; Perch, Williamson, Coloccini, Santon; Tiote, Gutierrez; Ben Arfa, Cabaye, Ba; Cisse.
Samuel Jackson says: "Hope Mancini starts with Aguero and Tevez and not Balotelli or Dzeko. As for Cisse and Ba I'm confident Kompany and co can contain them. 3 points a must today nothing else will do."
@efosanyang reckons: "Newcastle United really have to win this for both us (MUFC) and them. This is really an important game."
Darragh from Dublin writes: "Newcastle will be tough, especially at home, but I can't see City faltering with the title on the line. Gonna be a difficult game but I reckon 2-1 to City with Aguero and Nasri scoring for City, and Cisse getting one for Newcastle."
Newcastle unveiled a statue to honour legendary manager Sir Bobby Robson earlier on Sunday morning. Fitting tribute to a great man.
If you fancy a flutter on this afternoon's game, then our friends at Sky Bet have the following information for you. Manchester City (4/6) have won their last two games against Newcastle (4/1) 3-1. A repeat today is 12/1. Papiss Cisse has 13 goals in 12 Premier League appearances and is 7/1 to score first and 66/1 to score first in a 1-0 Newcastle win.
If you want to have your say on this afternoon's contest, then drop me a line to firstname.lastname@example.org or via Twitter @skysportsrobp and I'll publish a selection of the best.
Newcastle enjoyed an impressive 2-0 victory away to Chelsea in midweek, courtesy of Papiss Cisse's stunning double, and are now just two points adrift of Arsenal in third after the Gunners were held at home by Norwich on Saturday.
City took over at the summit on goal difference on Monday night courtesy of their tense derby success over United and can move three points clear with victory in the North East with the Red Devils not in action until later in the day, when they play host to Swansea.
This is a crucial fixture for both clubs, with Manchester City looking to press home their title advantage and Newcastle still in contention for a top three finish and a guaranteed return to the UEFA Champions League.
Good afternoon and welcome to our live and interactive commentary on today's clash at St James' Park.