Inverness trio Greg Tansey, Graeme Shinnie and Ross Tokely are suspended.
Jonny Tuffey is poised to continue as goalkeeper with Ryan Esson (groin) set to return to training next week, while winger Aaron Doran could play after being an unused substitute in the goalless draw with St Johnstone.
Defender Chris Hogg (knee) and midfielder Andrew Shinnie (foot) are long-term absentees, but the latter could feature before the end of the season.
Aberdeen left-back Clark Robertson has been ruled out of the trip.
The full extent of the knee injury Robertson suffered in training on Thursday is still to be determined, while striker Darren Mackie (illness) and midfielder Stephen Hughes (knock) are also out, joining Peter Pawlett, Mo Chalali, Isaac Osbourne, Rob Milsom and Yoann Folly in the treatment room.
Midfielder Gavin Rae is available again after being ineligible for the cup, while manager Craig Brown has said Jamie Langfield will start in goal and youth players Cammy Smith and Jamie Masson will be included in the squad.
Inverness (from): Tuffey, Golobart, Tansey, Foran, Tudur Jones, Tade, Gnakpa, Sutherland, McKay, Winnall, Ross, Proctor, Morrison, Williams, Mathieson, Meekings, Hayes, Doran, Gillet.
Aberdeen (from): Brown, Considine, Anderson, McArdle, Reynolds, Clark, Rae, Jack, Arnason, Vernon, Fyvie, Langfield, Fallon, Magennis, Megginson, Masson, Smith.