Town turned in one of their best displays under former Leeds boss Simon Grayson in the first leg at stadium:mk last Saturday as goals from Jordan Rhodes and Jack Hunt gave them a distinct advantage.
Dons manager Karl Robinson insists his side can complete a remarkable turnaround at the Galpharm Stadium and an early goal for the visitors would put them right back in the tie.
But Grayson, who replaced the sacked Lee Clark in February, said: "The first goal is important, but it isn't defining. If MK Dons get the first and we get the second goal then we're still in a good position.
"Without being big-headed, we believe we're good enough to win the game and finish off the tie."
Meanwhile, Luke Chadwick could come back into the reckoning for MK Dons ahead of the match.
Midfielder Chadwick missed the game on Saturday because of a knock he sustained against Walsall on the final day of the regular season.
Chadwick aside, the Dons just have the usual 'bumps and bruises' following the first leg, which sees them travelling to the Galpharm Stadium attempting to overcome a 2-0 deficit,
Robinson has options should he wish to make changes to his starting XI.
Mathias Doumbe or Tom Flanagan could come into the defence, with James O'Shea an option in midfield and Jabo Ibehre vying for a recall in attack.