Jack Collison is set to be fit for the Hammers.
Wales midfielder Collison scored both goals in the 2-0 semi-final first-leg win over Cardiff, but suffered a shoulder injury in the second leg at Upton Park.
However, the injury was not as bad as first feared and Collison was able to return to training on Thursday.
It means manager Sam Allardyce has a fully-fit squad available and can name the same line-up which started both legs of the semi-final and swept Cardiff aside 5-0 on aggregate.
The Hammers are looking for their third win of the season against Blackpool having won the league meetings 4-0 and 4-1.
Blackpool boss Ian Holloway has a virtually clean bill of health.
On-loan Liverpool defender Danny Wilson is the Seasiders' only absentee after picking up a calf strain and returning to his parent club for treatment, but the 20-year-old made the last of his 10 Seasiders appearances this term in the 2-1 defeat at Derby in early March.
Craig Cathcart is available again following heart palpitations but is unlikely to disturb the centre-back partnership of Ian Evatt and Alex Baptiste that has featured throughout Blackpool's ongoing nine-match unbeaten run.
Similarly, Roman Bednar (knee) is available, although a place in the matchday 16 will be a tall order for the Czech forward, with Stephen Dobbie and Gary Taylor-Fletcher established in attack and Kevin Phillips, Lomana LuaLua and Nouha Dicko all vying for a place on the bench.