Northampton manager Aidy Boothroyd has a full-strength squad at his disposal.
Boothroyd rested a handful of first-team regulars for the Johnstone's Paint Trophy first-round win over MK Dons - a game that also saw several fringe players enhance their claims for starting places.
Jake Robinson scored the only goal of the game in midweek, while there were also encouraging performances from Louis Moult, Ishmel Demontagnac and Henoc Mukendi on their full debuts.
Defender David Artell, midfielders Ben Harding, Luke Guttridge and Chris Hackett and striker Alex Nicholls were the players rested against MK Dons and they are likely to come back into the team.
Northampton did the double over AFC Wimbledon last season, winning the the first-ever meeting between the two clubs 3-0 before triumphing 1-0 in the return fixture at Sixfields.
AFC Wimbledon will check on Rashid Yussuff and Luke Moore.
Midfielder Yussuff (ankle) and forward Moore (knee) have not figured since the 6-2 defeat by Burton a fortnight ago but resumed training on Thursday and their fitness will be assessed.
Skipper Mat Mitchel-King remains on compassionate leave while fellow defenders Curtis Osano (ankle) and Curtis Haynes-Brown (concussion) are still sidelined.
Centre-half Callum McNaughton (cruciate) and striker Jason Prior (broken leg) are long-term absentees.
Boss Terry Brown must choose between goalkeepers Seb Brown and Mikhael Jaimez-Ruiz after the latter's impressive debut in the narrow defeat against Southend in the JPT on Tuesday.
Pim Balkestein and Christian Jolley should return after starting on the bench in midweek.