The Red Devils wind down the clock in possession as they close out a second stanza of vintage football from the 19-time English champions.
Some sagging heads from Martinez's men as they prepare themselves for a losing bus trip back home to the DW Stadium.
No let up from the hosts as they easily deal with a late attacking burst from the Latics to launch a promising counter-attack of their own.
Hernandez bursts towards the box once more as the match enters the final stages, with three extra minutes added on.
The Dutchman's delivery from the dead-ball is cleared, but United attack again from the rebound.
Van Persie goes down outside the area and earns United an attacking set-piece.
No luck for Rafael as he receives the ball out on the right only to scuff his shot. However, his effort would've been ruled offsides has it gone in.
Powell with the run that takes him into the danger area but the pass from Nani doesn't find the United goalscoring debutant.
Nani, again, in possession and making a telling run towards to box but his latest dash is smothered out on the right.
Nani blazes down the right flank with Hernandez and Welbeck both bursting towards the box at pace, but the winger's delivery sails just over the duo.
Hernandez pressing with intent and tries to loft a ball into the box for Welbeck.
82 Powell with a thunderous strike from outside the area after the Latics make a hash of things clearing a loose ball off Welbeck.
Latics battling to keep the Red Devils at bay with Welbeck a nuisance in the danger area once again.
Van Persie receives the ball inside the area but the Dutch ace's effort lack the direction.
Ferguson shouting intructions from the sildeines for his men to keep pressing for another goal.
Powell looking good on the ball with his first few touches of the game and looks confident and self-assured going forward and in tandem with his team-mates.
United dominating possession and squeezing the Latics off the ball at every give and turn.
76 Nemanja Vidic earns a break for Jonny Evans to take to the field to a rapturous applause from the home supporters.
The Red Devils bossing the midfield and forcing the Latics middle-men to backtrack.
Van Persie gets his first touch on the ball inside the area but the defenders are alert to the danger and his effort is meek.
Latics seem to have given up the ghost on attack and are laying back in an effort to smother the wave after wave of attacks from United.
An attempt at a one-two-goal from Rafael and Hernandez on the right should've seen the Brazil full-back score Untied's fourth from close-range.
Double change from Ferguson sees Giggs and Scholes come for Van Persie and Powell.
The Red Devils slowing play down at the back and quelling the latest foray from the Latics.
United having to do some work on defence right now as the visitors continue to push.
Latics back in possession but not able to do much with it for the moment.
Latics find themselves inside the Red Devils' box but the defence manages to hack a loose ball clear before Di Santo can a foot to it.
It's seems Latics sails have deflated and United's spirits lifted as the hosts surge forward with earnest.
65 An incredible run from Buttner down the left, and some good favour off a defender's feet, sees Patrice Evra's replacement score from an acute angle off Habisi.
With a two-goal cushion, the odds are in Untied's favour to start asserting their dominance on the encounter.
63 Hernandez nicks United's second after he deflects Buttner's shot on goal into the back of the net.
Latics clear the corner-kick danger but the Red Devils are almost camped inside their opponents half now and are hustling to regain possession.
Nani, again, this time running strong down the right and drifts into the area but his cross is blocked by Caldwell and bundled into touch,
Nani and Welbeck looking to combine on the break for United, but the Latics defence shuts them down,
Welbeck, again, this time his shot from outside the box is blocked by Figueroa.
Going a goal behind has certainly inspired the visitors who look the more likely to score at this stage.
Back on the ball, the Red Devils are pressing hard and playing the ball out to the flanks.
United battling to contain the Latics as they dominate the middle of the park.
Martinez's men are fired up now and are trying to catch the Red Devils on the fast-break, Beausejour ever-present on attack.
Latics, maybe a little shell-shocked having had the lion's share of possession since the restart, are heading upfield and looking eager to draw level.
The Red Devils, having gone one goal up, look more alive and are pressing with earnest and verve in pursuit of another.
Welbeck, again, this time with a a shot towards to the top right corner after a fast restart from Untied having gone ahead moments earlier.
51 Scholes taps in from close range after a super ball in to box from Nani on the right causes some confusion among the Latics defenders.
While Hernandez's header from the set-piece fails to cause any real danger, United remain inside the area and continue to probe for an opening.
Buttner, again, gets into a good advance position down the left side and earns his side a free-kick in a good attacking position.
Kone almost capitalises on Ferdinand's mistake at the back but the United defender recovers quickly and regathers the ball before the Latics ace can dispossess him.
Latics looking to assert their authority on the game in the second stanza with several ambitious balls fired into towards Kone upfront.
Latics get us back underway!
As a United fan, can I ask Sir Alex to give Nani to Hartlepool? I have never seen him have a good game for us, this game is no different. United look weak all over the park, especially the midfield, they have no control in the match. Very poor 1st half. shep
Dangerous set-piece into the United box from the right has Kone going down low to try and get off a header, but no luck for the visitors.
United ease on their attacking forays as the half enters two minutes of added time.
Welbeck goes down hard under a challenge, but after a few minutes of medical attendance the striker manages to finally get to his feet and continue.
Beausejour, again, plays in a good ball across the face of goal for the Latics from the left that takes a deflection from Rafael and falls for Arouna Kone at the far post, who should've done better with his shot.
Latics seem keen to sit back now and wait to hit United on the counter-attack.
Beausejour's left-footed cross into United's box for Boyce looks good in the air but Lindegaard is alert to danger and gathers the ball well.
United working feverishly in and around the box through Nani and Welbeck as the first half enters the final five minutes.
Hernandez with a half-run towards goal to chase a long ball, but the Mexican pulls up knowing he'll be called offsides.
Di Santo and Beausejour attempt to link up down the left and it takes some scrambling defensive work from Rafael to clear the ball into touch.
Latics moving up into United's half at pace through Di Santo, but he's closed down by Ferdinand.
The Red Devils making all the play but the final scoring shot continues to allude them.
Giggs with a beautifully flighted cross for Nani on the run, the winger then trying a lifted chip from the left of the box that just has too much on it and sails over the bar.
Beausejour runs hard down the left but Scholes puts in a challenge and receives the referee's favour and gets a free-kick.
Buttner delivers a low cross for Welbeck at the left post, but his shot is smothered.
Buttner's deep cross into the box for Hernandez is headed clear by Maynor Figueroa.
United, again, trying to push up from deep and catch the Latics defence on the counter.
Great tackle from Buttner on Di Santo on the left as the striker moved at pace into the United box on the right.
Latics making some moves down the flanks, lookg for Franco Di Santo in and around the box.
The Red Devils still with the ball but not finding it as easy to push upfield now with the Latics midfield pushing up stronger and closing the space down sooner.
Buttner makes a decent run into the 18-yeard area but the cover defence gets to him in time to fluff his attempt at a cross from the left.
Boyce with a right-footed shot from just outside United's area but it goes wide. However, even if it went it in it would've been ruled out for offsides.
Latics trying again to push from midfield, but this time making some headway through McArthur.
Well-weighted cross into the box from Michael Carrick for Welbeck sees the forward make another decent effort on goal, the ball flying just over the crossbar this time.
Emmerson Boyce's header is decent but just wide to the right of Lindegaard.
Much better play from the visitors as they manage to work their way into Untied's half and earn themselves a free-kick out on the right.
Latics clear the danger from two United corner-kicks, but it's Scholes' 50-50 tackle on Gary Caldwell inside the area that draws some gasps from the travelling Latics supporters.
Welbeck, again, with an effort on goal, this time from just outside the box but it's deflected out for a corner.
Latics are not doing enough to close down the space for Untied to build their play from deep inside their own half.
Great turn and shot from Welbeck after Nani supplied him inside the area, the striker's shot just wide to the left of goal.
Rafael trying to make a break down the right but the Brazilian is shut down.
Buttner, again, with a strong run down the flank as he looks to link up with Welbeck. A solid debut thus far, but it is still early in the match.
Latics getting more into the game, varying their play but only for the long ball strategy to let them down a touch.
Long ball for Welbeck has the striker surging into the area and trying to drill in a left-footed shot at the near post, but the cover defence gets there to put him off.
In response to feedback, Buttner has looked good so far with the Dutch defender just no able to deal with a long ball and coolly playing it back to Rio Ferdinand.
Latics still trying to play as much of the game inside United's half but Welbeck and Hernandez are doing a good job dropping back and bolstering the defensive numbers.
Scholes and Ryan Giggs trying to link up in the middle of the park with the veteran duo able to provide some decent ball for their forwards.
Latics struggling to gain some ascendency in the game with the Red Devils rushing them on defence.
Buttner shows his worth early on with a good run down the left and then a sharp cross into the box, which cleared out by the defence.
United still seeing more of the possession and building patiently from the back.
Welbeck allowed to run at the Latics defence but he holds onto the ball seconds too long and is dispossessed before he tee up a team-mate.
Penalty save from Habisi, who guesses right and dives low to his left to deny Hernandez.
4 Penalty for Welbeck! The England striker gets the slightest of contact from Ali Al Habsi after a long ball into the area from Nani.
Beausejour receives strong word from the referee early on for an over-eager challenge on Nani.
Nani plays a good ball from the right towards Danny Welbeck in the area, who gets a head to the ball but not on target.
United get the match under way from right to left!
I predict a 4-0 win for Man utd Scholes (1) Rvp (2) and Buttner (1) from Hardy :) Hardeev Badhen
Landmark day for former England midfielder Paul Scholes, his 700th appearance for the 19-time English champions.
As a United fan I think this will be a harder game than some may think, but I think we may clinch a 2-1 victory today. I'd also like to see Nick Powell come on as a substitute to see what he can bring to today's game, would be interesting to see what he can bring to the field! Josh Scott
I predict a 3-1 utd win. Brenda from Ghana.
I've got nothing but admiration for the job Martinez has done at Wigan, and I think all three of the title chasing teams- United, City and Chelsea- are involved in potential banana skin games. Man United's defence has looked a shaky of late and Wigan will go to Old Trafford with no fear the way Martinez sets his team out to attack the big teams. I've actually got a feeling Wigan might get an early goal which would make Old Trafford a bit edgy, and with Rooney and van Persie having fitness problems, you never know how things might pan out. To be controversial, I'll say Wigan can nick a point, 1-1! Gabriel Sutton
Feel free to e-mail your thoughts or predictions to firstname.lastname@example.org and we'll publish as many of them before - and during - the game as possible.
Meanwhile, Jean Beausejour (hamstring) and James McArthur (back) are passed fit and take their spot in the starting XI for the Latics. However, Antolin Alcaraz is not so lucky and misses out altogether due to injury.
Van Persie and Shinji Kagawa are both on the bench for United, along with former Latics loanee Tom Cleverley and summer signing Nick Powell, as a precautionary measure after the duo returned from international duty with respective thigh and back niggles. Javier Hernandez and Danny Welbeck are paired together in attack, with full-back Alexander Buttner will make his debut. Anders Lindegaard will also start in goal ahead of David de Gea.
Wigan are rated at 12/1 to beat Man United today according to our friends at Sky Bet, while it is 5/1 for the match to end in a draw. Van Persie is 9/4 to score first and 6/1 to secure a hat-trick. Also, the Red Devils are 15/8 to reclaim the Premier League title.
Meanwhile, Latics manager Roberto Martinez has thus far seen his side lose just once this season - to Chelsea, with their only victory a 2-0 win over the Saints.
United, in fifth spot, will be looking to gain momentum to what has been an indifferent start to their campaign. Sir Alex Ferguson's side made hard work of their last top-flight encounter, the 3-2 win away at Southampton secured thanks to Robin van Persie's late brace.
Good afternoon, I'm Devin Hermanus and I'll be taking you through all the action as Manchester United host Wigan at Old Trafford. Kick-off is scheduled for 1500 BST.