The O's were given an early boost after three minutes at Brisbane Road when Chorley headed on a long throw from fellow centre-half Nathan Clarke which left Glovers keeper Marek Stech flat-footed.
Brunt doubled the lead after Lee Cook delivered an inch-perfect cross from the left to the far post where the unmarked striker rose to powerfully head the ball home.
The visitors were revitalised by a goal from Sam Foley after 55 minutes after a cross from Korey Smith eluded the home defence.
It was a false dawn, though, with Smith restoring the two-goal cushion after 71 minutes when he netted from three yards from Gary Sawyer's corner.
And 11 minutes from time O's keeper Ryan Allsop's goal-kick was headed on by Brunt and Lisbie raced onto the ball and slipped it between the legs of Stech to complete the rout.