Boss Dean Saunders will check on midfielder Martin Woods and striker Billy Paynter before Doncaster move on from their Norwich base to London.
Saunders' side played Norwich in the Capital One Cup on Wednesday night and stayed in East Anglia ahead of Saturday's League One game at Brisbane Road.
Woods suffered an ankle injury during the first half of the 1-0 defeat to the Canaries. Paynter has been nursing a thigh problem and did not feature in the third-round tie.
"Woodsy twisted his ankle and that's why I brought him off early in the second half," said Saunders.
"There was no point risking making it worse when there were fit players on the bench looking to get on. I don't think it's too bad but we'll see how he is.
"Hopefully Billy will be okay to play some part [on Saturday], but if he isn't quite ready we aren't going to rush him back. We have to give his thigh injury time to heal if it's not right."
Leyton Orient will be without Anthony Griffith through suspension.
Griffith serves a one-match ban after he was sent off for a second bookable offence in the final minute of last weekend's draw at Crewe.
Fellow midfielder Martin Rowlands will be handed a late fitness test.
The former QPR playmaker, who this week agreed a new contract with the O's, was taken off at half-time on Saturday with a hamstring problem and is rated 50-50 by manager Russell Slade.
Defender Scott Cuthbert (hamstring) and goalkeeper Jamie Jones (shoulder) are still on the sidelines.
Orient are unbeaten in four games and will leapfrog Doncaster in the table with a win.