Monakana levelled for North End after the break, cancelling out Gavin Williams' early penalty for the Glovers. He then set up Chris Beardsley to head the hosts 2-1 up and was tripped for the yellow card that led to Ed Upson's dismissal.
The afternoon got off to a bad start for Preston as keeper Thorsten Stuckmann tripped Gozie Ugwu in the area, with Williams converting the spot-kick.But in the second half Monakana took over, equalising in the 57th minute after latching on to a cross from Will Hayhurst.
Seven minutes later, the pacy winger's centre was headed in at the back post by Beardsley.
There was no way back for Yeovil when Upson brought down Monakana in full flight, earning his second booking.
And the home side sealed victory with six minutes left when the unfortunate Dan Burn scored an own-goal on his Football League debut. Burn made amends a minute later by heading in a Jamie McAllister free-kick, but there was no way back for Yeovil.