High-flying Tranmere will put their unbeaten record on the line with very few injury worries to consider.
Manager Ronnie Moore, whose side top the League One standings, had only one absentee on the training ground this week.
Defender Ian Goodison continues his recovery from knee surgery but is expected to feature for the reserves next week.
Rovers' second string had a game scheduled for this week but it was cancelled due to bad weather, denying defender Paul Black (thigh) and forward Adam McGurk some much-needed game time.
Moore revealed spirits were high at Prenton Park and he is keen to see the good run continue.
"Everybody wants to play, everybody wants to be part of it," he told the club's official website. "We've got quality here and self-belief and that's something you want in the dressing room."
Brentford will check on Jonathan Douglas and Simon Moore ahead of the game.
Both players were sent to hospital after suffering hand injuries during last weekend's win over Oldham.
Combative midfielder Douglas will be expected to play but the injury will obviously be of more concern to goalkeeper Moore.
Young midfielder Adam Forshaw scored his first senior goal against the Latics and keeps his place despite a niggling abdominal problem.
Boss Uwe Rosler has hinted he could make changes, though, with defender Leon Legge, midfielders Sam Saunders and Ryan Fredericks and striker Paul Hayes pushing for places.
Full-back Shaleum Logan plays against his old club.