Adam Chambers has failed to recover in time to face former club Leyton Orient as Walsall look to continue their impressive start to the season.
The midfielder has been missing for over a month with a hamstring injury and had hoped to be fit by now, but a setback in his recovery means he will again sit out against his old employers.
Twin brother James has also been sidelined for a similar period with a thigh problem and the full-back remains a couple of weeks away from his return.
Back-up goalkeeper Jimmy Walker (thigh) continues to watch from the sidelines, but manager Dean Smith has no new injury or suspension problems.
Smith guided the sixth-placed Saddlers to their fifth league victory of the season on Saturday as they saw off Bournemouth 2-1 late on at Dean Court.
And his side will be aiming for a third successive win when they entertain a mid-table Orient outfit winless in two.
Anthony Griffith returns to the Leyton Orient squad.
Griffith missed Saturday's 2-0 defeat at Doncaster through suspension after he was sent off the week before at Crewe.
Fellow midfielder Martin Rowlands will be handed a late fitness test.
The former QPR man was rated 50/50 for the weekend due to a hamstring problem but was not passed fit.
Manager Russell Slade will be hoping to reunite his first-choice midfield pairing after they were badly missed as Orient slipped to their first defeat in five matches.
Full-back Lloyd James and striker David Mooney were on the bench on Saturday after their recent lay-offs but centre-half Scott Cuthbert (hamstring) and goalkeeper Jamie Jones (shoulder) are still on the sidelines.