Oxford boss Chris Wilder remains without a number of senior players.
Pressure has mounted on the U's boss in recent weeks with a number of fans protesting but chairman Ian Lenagan insisted Wilder will not be judged until he has a fully-fit squad at his disposal.
Striker Jon-Paul Pittman remains sidelined with a hamstring injury while Michael Duberry (neck), Liam Davis and Andy Whing (both groin) are still in the treatment room.
Adam Chapman is also unavailable but Wilder was boosted by the return of Harry Worley, Jake Forster-Caskey and Peter Leven for the defeat at Rotherham.
Defender Worley recovered from an ankle injury while Forster-Caskey shook off a bout of illness. Midfielder Leven was only fit enough for a place on the bench after a knee injury and could be in contention for a starting place.
Curtis Osano could make his full debut for Wimbledon.
The defender had been sidelined with an ankle injury since he arrived at Kingsmeadow in the summer, but had an injection last week to speed up his recovery and made his first appearance as a substitute against Accrington on Saturday.
Osano replaced Watford loanee Dale Bennett, who had to go off with a back injury and is a doubt for Tuesday, while fellow defenders Mat Mitchel-King (back) and Pim Balkestein (groin) are still on the casualty list.
But midfielder Stacy Long, who missed the Accrington defeat, could be back ahead of schedule after an X-ray revealed his foot injury is not as serious as first feared.