Argyle boss Carl Fletcher will check on the fitness of Onismor Bhasera and Warren Feeney.
The duo were both replaced during the 1-1 draw with Wycombe in midweek.
Midfielder Bhasera received a cut to his cheek while striker Feeney suffered a groin injury and Fletcher took the precaution of withdrawing them as the Pilgrims stretched their unbeaten run to four games.
Durrell Berry returns after serving a one-match ban for picking up five yellow cards and is expected to replace Curtis Nelson at right-back.
Loan duo Alex MacDonald and Guy Madjo could be making their last appearances for the club as their deals run out after the game, but Fletcher is hopeful the club can keep the pair for another month.
Veteran midfielder Paul Wotton is still sidelined with a groin problem and will play no part.
AFC Wimbledon have a host of injury doubts.
Centre-halves Dale Bennett, Mat Mitchel-King (both back) and Pim Balkestein (groin) are expected to miss out again.
Full-back Curtis Osano's ankle injury will be checked over along with midfielder Stacy Long, who is close to returning from a foot injury.
Defender Callum McNaughton (knee) and striker Jason Prior (broken leg) remain long-term absentees.
Simon Bassey will take charge of what looks like being his last game as caretaker boss.
The Dons now have a shortlist of three candidates to replace Terry Brown, who was sacked last month, and hope to have a new manager in place by the time they face Cheltenham next Saturday.