Colchester boss Joe Dunne will likely keep faith with the same XI who ended Stevenage's unbeaten record.
The U's got back to winning ways with an impressive 1-0 success over Boro last weekend and, with no major new injury or suspension problems, Dunne is set to see no need for change.
Defender Matt Heath was an unused substitute but he will miss out against the Cumbrians having picked up a hamstring injury.
Returning midfielder John-Joe O'Toole (groin) bagged a brace in a 2-1 friendly win over West Ham on Tuesday, but manager Dunne feels he needs another week of training under his belt before a first-team comeback.
Fellow midfielder Kem Izzet (hip) also continues to miss out while striker Clinton Morrison serves the second game of his three-match suspension.
Carlisle striker Danny Cadamarteri will return to contention for the game.
The former Everton forward missed the midweek draw at Bury due to a groin strain, but is expected to return to the starting line-up alongside Joe Garner, whose loan spell from Sunderland was extended this week.
Teenager Dave Symington recovered from shingles to step off the substitutes' bench on Tuesday and is also back in contention, but fellow winger Jon-Paul McGovern is set to miss out again due to the hernia problem that has forced him to miss the last three matches.
Abbott has no new injury or suspension problems, but forward Lee Miller remains sidelined with a long-term ankle injury.
Defenders Alessio Bugno and Danny Livesey, midfielder Brad Potts and teenage striker Mark Beck all had midweek run-outs in the Cumberland Cup win over Longtown and are pushing for a place in Greg Abbott's starting line-up.