Oldham manager Paul Dickov will run the rule over captain Dean Furman.
Furman returned to Boundary Park following trips to Poland and Kenya while on international duty with South Africa and the midfielder is expected to make the starting XI on his return to club duty.
Dickov is boosted by having a fully-fit squad to choose from and the news that on-loan Manchester City defender Reece Wabara has extended his stay for a further month, as Latics look to make it four games unbeaten.
Striker Matt Smith is set to be involved once more after prodding home an equaliser deep into stoppage time at Sheffield United last weekend before netting a brace for the reserves against Walsall in midweek.
He told the Manchester Evening News: "I think we are fearless now. We are high on confidence and I think we believe we can beat anybody.
"Perhaps that has been the case more away from home where you are the underdog. But the way we are playing and the results we have had recently, compared to the start of the season, I think we have a point to prove. We want to make Boundary Park a fortress and there's no reason that we can't do that."
Leyton Orient boss Russell Slade is again likely to be without striker Kevin Lisbie.
The veteran forward is still nursing a hamstring problem and is likely to remain sidelined for a further two weeks.
Ryan Brunt and Scott Wagstaff are set to lead the line again although Michael Symes and David Mooney are both pushing for inclusion.
Midfielder Lee Cook may return to the starting XI having been rested for the midweek win over Hartlepool.
Slade is unlikely to make too many changes, though, as Orient aim to record back-to-back wins for only the second time this season.
Centre-half Scott Cuthbert remains on the sidelines with his hamstring problem while goalkeepers Jamie Jones (shoulder) and Lee Butcher (knee) are also long-term absentees.