Fleetwood will once again be without Andy Mangan after the striker suffered a setback in his rehabilitation from a knee injury.
Mangan returned to action in a midweek behind-closed-doors friendly and opened the scoring before leaving the action with a recurrence of the problem.
Dean Howell returned to training this week following an ankle injury suffered in the draw at York but is unlikely to be risked at this stage, while fellow defender and captain Steve McNulty remains on the sidelines with a calf injury.
Recent loan signing Rob Edwards is expected to make his second appearance for the Cod Army at centre-back in the skipper's absence.
Last week's surprise 1-0 home defeat against Wycombe saw Cheltenham edge Fleetwood out of the automatic promotion places.
Neal Ardley will be hunting his first win in charge of AFC Wimbledon but will do so without the help of several players.
A quartet of players missed his first game in charge, the 2-1 home defeat to Plymouth, and all four are likely to miss out again.
Mat Mitchel-King and Dale Bennett, on loan from Watford, both have back problems, with fellow defenders Pim Balkestein and Callum McNaughton sidelined by groin and knee problems respectively.
Striker Luke Moore will continue up front and he is relishing the opportunity to get Wimbledon's season back on track.
"The results have not been going for us lately," he told Dons Player. "In patches of games we have been playing better football than the other teams and we will go there with confidence that we can get a result."