Crawley are without Joe Walsh.
The defender was ruled out of Saturday's 1-0 win at Hartlepool after suffering a hamstring injury in training.
Walsh will not return for the first-ever meeting between the two clubs and is a major doubt for the weekend clash with Oldham.
Claude Davis returned from a thigh problem to replace Walsh against Pools and will continue in defence.
Walsh joins Shaun Cooper on the treatment table. The midfielder picked up a groin injury versus Colchester last month and has not featured since.
Boss Richie Barker has no further injury worries and is unlikely to make any changes as they face Karl Robinson's Dons.
MK Dons will hand a late fitness test to midfielder Stephen Gleeson.
The Irishman's foot injury which he sustained in the 1-0 defeat against Stevenage on Saturday is not as bad as the club first feared but there are no guarantees he will recover in time for the trip.
Summer signing Antony Kay could be recalled from the bench after returning from suspension last time out.
Boss Karl Robinson, who was only able to name five substitutes at the weekend, remains desperately short of numbers.
Centre-half Gary MacKenzie is sidelined for around three months, while Daniel Powell and Dean Bowditch are expected to miss out once again as both players are carrying knocks.