Shrewsbury will be without suspended leading scorer Marvin Morgan.
Morgan bagged his fifth goal of the campaign to put Shrews back in contention at Portsmouth on Saturday but was shown red immediately straight from the resulting kick-off.
The striker, already on a booking, brought down Brian Howard before his furious reaction at the soft decision brought a second yellow card and a subsequent red from referee Fred Graham. Morgan now serves a two-match ban after Shrewsbury opted not to appeal.
Morgan's unavailability is likely to mean a starting berth for one or both of fit-again frontmen Terry Gornell and Sam Winnall, with Morgan Town's only out-and-out striker in recent weeks.
Defenders Darren Jones and Joe Jacobson could also earn recalls to manager Graham Turner's starting XI having overcome illness and injury respectively of late.
Back-up goalkeeper Joe Anyon (hip) will be assessed after 42-year-old goalkeeping coach Gavin Ward was forced to take his place on the bench in the 3-1 defeat to Pompey.
Yeovil captain Jamie McAllister is one of four injury worries for manager Gary Johnson.
The Scotland international limped off with 15 minutes left of the Glovers' 2-1 victory over 10-man Bury on Saturday and he will be assessed by the club's medical staff before a decision is made on the 34-year-old left-back's fitness.
Keanu Marsh-Brown was replaced at half-time on Saturday by Gavin Williams and the Welshman is expected to deputise should the 20-year-old's bruising not die down.
Korey Smith and Ed Upson are likely to shake off the knocks picked up against Kevin Blackwell's men while on-loan Reading striker Gozie Ugwu could come back into contention after recovering from a hamstring injury.
Defender Luke Ayling remains on the sidelines with a hip problem.