Rochdale boss John Coleman is once again set to be without Craig Curran and Ray Putterill.
Forward Curran serves the final game of a three-match ban for his red card in the Johnstone's Paint Trophy clash with Bury, while Putterill is doubtful with the groin problem that has ruled him out of Dale's last two matches.
Coleman suggested a tactical reshuffle could be in the offing on his side's return to Spotland following the 3-1 weekend loss at Plymouth.
"You start with self-analysis," he said. "I have got to look at where I could have done better - whether I could have done better with my team selection, whether I could have done better with my tactics."
Reece Gray (broken leg) and Matt Edwards (wrist) remain long-term absentees.
Oxford captain Jake Wright returns from suspension and he rejoins a side that are on a high after a 5-0 victory over Accrington on Saturday.
The 26-year-old's fifth yellow card of the season, picked up during his 100th game for the U's at Port Vale, meant he had to watch the impressive win from the stands.
Striker James Constable was given the captain's armband in Wright's absence and, while strike partner Tom Craddock grabbed the plaudits with his four goals, Constable was described as "back to his best" by manager Chris Wilder.
"If I was Tom Craddock I would be shaking Constable's hand because I thought his game was superb and he deserved a goal," he told the club's official website. "He played a major part in us getting the result."
Meanwhile, left-back Tony Capaldi will have his ankle injury assessed before kick-off.