Rotherham will again be without goalkeeper Scott Shearer.
The 31-year-old had knee surgery on Friday and now faces up to six weeks on the sidelines, so veteran Andy Warrington will continue in the Millers goal.
Midfielder David Noble missed Saturday's first away win of the season at Aldershot after struggling with a virus and is now back in training, but he is unlikely to play with on-loan Lee Frecklington forming an impressive partnership with Kari Arnason.
Indeed, Millers boss Steve Evans is unlikely to make any changes to his side after an encouraging display in Hampshire at the weekend, so Daniel Nardiello and Alex Revell will continue in attack.
On-loan defender Bob Harris will play the final game of his loan spell, but Evans will speak to Blackpool manager Ian Holloway on Tuesday in a bid to extend the deal.
Morecambe will be without suspended striker Richard Brodie.
On-loan Crawley striker Brodie received a straight red card during stoppage time in Saturday's 1-0 win over Southend and must begin a three-game ban.
Shrimps winger Izak Reid was absent due to illness at the weekend but is expected to return to Jim Bentley's matchday squad, most likely among the substitutes.
Bentley is still without left-back Robbie Threlfall (thigh), while forward Danny Carlton (knee) is a long-term absentee.
Ryan Williams signed a short-term deal with Morecambe at the end of last week having spent pre-season on the Lancashire coast but the Welsh midfielder must be granted international clearance before making his debut.
Victory at the New York Stadium would give Bentley's men three consecutive wins for the first time this season.