Striker Billy Clarke is set to continue up front for Crawley after making a goalscoring impact in midweek.
Clarke bagged both goals in the 2-0 win over MK Dons on Tuesday night, in his first start in League One since the opening day of September against Leyton Orient.
As a result Clarke will keep his place against the Latics but Dannie Bulman, who was recalled by manager Richie Barker against the Dons for his first league start in five weeks, is a doubt after suffering a groin injury late on in that match.
Defender Joe Walsh is also a major doubt with a hamstring injury which has kept him out of the last two matches but his replacement Claude Davis has helped Crawley win both those fixtures without conceding a goal.
Shaun Cooper is still having treatment on a groin injury which he sustained against Colchester last month and is not expected to feature.
Matt Derbyshire is an injury doubt for Oldham.
On-loan Nottingham Forest striker Derbyshire has scored four times in nine starts since moving to Boundary Park but suffered a rib injury during Tuesday night's 3-1 defeat at Carlisle.
Latics boss Paul Dickov is still waiting to discover the severity of the problem before ruling out the 26-year-old.
"Matt was a bit better on Thursday again so we'll just wait for the results of the x-ray," he said.
"If his rib is broken then he'll be doubtful for Saturday but if it's bruising then hopefully he'll be okay."
Centre-back Jean-Yves Mvoto has recovered from a head injury suffered at Brunton Park, where Oldham's run of four league games unbeaten was brought to a halt.