Scunthorpe midfielder Michael Collins could make his first start in 13 months.
Collins, who made only three appearances last season, had been sidelined since the summer of 2011 with an Achilles injury but has stepped off the substitutes' bench in the last two matches and is hoping to play a bigger role.
Winger Andy Barcham remains doubtful with the ankle injury which kept him out of the midweek home defeat to Preston but skipper Paul Reid, who made only his second start of the season on Tuesday after hand, groin and calf injuries, will be back in contention despite being forced off in midweek with an eye problem.
Leading goalscorer Leon Clarke and Mark Duffy missed training this week due to minor knocks but are expected to be fit while midfielder Damien Mozika (ankle) is not yet ready, although he is closing in on his return following a long-term lay-off.
The Iron have taken only two points from their last six league matches.
Dean Bowditch could be back in contention for MK Dons as they look to re-ignite their season.
Bowditch has missed the back-to-back defeats to Stevenage and Crawley with a knock but the midfielder hopes to be included in the squad that travels to Glanford Park.
Stephen Gleeson suffered severe bruising to a foot against Stevenage last weekend but was able to make the bench in midweek at Crawley and is expected to return to the starting line-up alongside Darren Potter in the middle of the park.
Defender Gary MacKenzie remains a long-term absentee with a hip problem.
The Dons are without a win in five League One matches and have slipped to 10th in the table, and boss Karl Robinson expects a response against the Iron.
"We must all roll our sleeves up," he said. "We've got to move on and stand up and be counted and come back strong on Saturday. I've been in worse positions than this. Back when I first took over after Paul (Ince) left we were a lot lower down, with a lot less points, but we turned it around and I'm sure we'll do it again."