Rotherham boss Steve Evans will be forced into at least one change for the visit of the Pilgrims.
The Millers, who have won back-to-back games for the first time this season following Evans' return to the dug-out after a six-match stadium ban, will not be able to call on Bob Harris.
The 25-year-old left-back's 28-day emergency loan from Blackpool has ended and the Championship club have refused to extend the deal.
However, that loss has been off-set by the signing of Josh Morris on an emergency loan from Blackburn and he will fight for a place in Evans' starting XI along with fit-again Laurie Wilson, who has been out for the last eight games with a knee injury.
Goalkeeper Scott Shearer faces another four or five weeks on the sidelines after undergoing surgery to repair cartilage damage in his knee so veteran Andy Warrington will again keep his place in the side.
Evans is unlikely to change the rest of his side around too much, but remains in the market for a striker and back-up keeper.
Plymouth are set to hand Jamie Lowry his first start for the club in place of Conor Hourihane.
Hourihane was controversially booked for diving in Tuesday's defeat to Cheltenham and his fifth yellow card of the season means he will serve a one-match suspension.
With Ross Jenkins having returned to parent club Watford with a groin injury and Paul Wotton ruled out for two months after a back operation, it opens the door for Lowry to line-up in midfield.
The summer acquisition from Chesterfield picked up an ankle injury during pre-season and made his Pilgrims debut as a late substitute at Whaddon Road.
Welsh striker Rhys Griffiths' groin injury means he is also a doubt for the trip to South Yorkshire.