Wycombe attackers Dean Morgan and Bruno Andrade are both doubts for the M40 derby.
Morgan was substituted in the first half of their 0-0 draw with Barnet on Tuesday with a hamstring problem while Andrade did not feature due to a bruised foot and is rated 50/50 to return to action against Chris Wilder's side.
There are also question marks over the availability of defenders Danny Foster and Leon Johnson who both missed Tuesday's clash.
Gareth Ainsworth's selection worries have been eased slightly by the return of former Torquay striker Jo Kuffour after suspension.The 30-year-old missed Tuesday night's game after a first-half red card against Port Vale.
Matt Bloomfield, Dennis Oli and Marvin McCoy all remain on the comeback trail after injury.
Oxford captain Jake Wright is expected to return to the starting line-up in place of the suspended Michael Raynes.
The former Rotherham defender chalked up his fifth yellow card of the season at Rochdale with Wright an unused substitute at Spotland.
On-loan Swindon midfielder Lee Cox took the train home from Lancashire on Tuesday after suffering from a virus and the 21-year-old has been kept away from his team-mates and will be assessed prior to kick-off.
The U's have lost their last two away games without scoring a goal and have not won at Adams Park in their last five meetings in all competitions.
Defeat for Oxford would leave them just one point ahead of Gareth Ainsworth's side.