Preston manager Graham Westley hopes to welcome John Welsh back into his midfield.
Welsh served a one-match ban having collected five yellow cards when the Lilywhites dispatched Yeovil 3-0 in the first round of the FA Cup on Saturday, but Westley suggested the break came at an opportune time as the former Tranmere skipper was carrying a minor knock.
North End club captain John Mousinho is set to miss out once more but will target Saturday's trip to former club Stevenage on Saturday as a comeback date following a debilitating bout of mumps.
Ex-Southampton winger Lee Holmes came off the bench on Saturday to make his first appearance since suffering a gashed knee in August and is pushing for inclusion once more.
Lee Trundle, 36, remains unavailable but the forward hopes to return to full training next week following knee surgery.
Carlisle will be without Paul Thirlwell and teenager Mark Beck again, while Chris Chantler and Matty Robson are both doubtful.
Midfielder Thirlwell sat out Saturday's FA Cup win over Ebbsfleet due to an ankle injury, while striker Mark Beck also missed out after breaking his finger at home on Friday night.
Fellow midfielder Chantler is struggling with a heel problem which forced him off late in the game at the weekend and winger Robson is hoping to return after having an injection to aid his recovery from injury.
Defender Peter Murphy shook off a hamstring strain to play in an unaccustomed holding midfield role against Ebbsfleet, but manager Greg Abbott must wait and see if Danny Livesey is fit enough to play after sustaining a hand injury on Saturday.
Winger Jon-Paul McGovern is pushing for a recall to the starting line-up after returning from a groin injury to make his first appearance in seven matches at the weekend.