Luke Summerfield and Terry Gornell hope to be back up to full fitness in time for Shrewsbury's crunch trip to fellow strugglers Leyton Orient.
Midfielder Summerfield missed his first game of the season as he was dropped to the bench for Tuesday's 2-1 defeat at Bournemouth nursing a sickness bug.
Striker Gornell has also sat out of training with a similar virus, while Town are now keeping an eye on Mark Wright.
Manager Graham Turner explained on the club's official website: "Luke's still a bit groggy but he's wanted to train (on Thursday) and get some work under his belt. It was very unfortunate for him as I think he's been one of our better players this season."
New signing Luke Rogers will go straight into the squad having rejoined his former club on an initial loan deal that will become permanent when the transfer window opens in January. The 30-year-old scored 65 goals for the Shrews in his first spell before leaving in 2005.
Fourth-from-bottom Shrews travel to Brisbane Road one place and two points behind the O's.