The Cobblers are boosted by the return of a handful of players ahead of the Chairboys' visit.
Midfielder Chris Hackett missed the FA Cup replay at Bradford in midweek through illness, while leading scorer Adebayo Akinfenwa was only fit enough for a place on the bench against the Bantams due to a sickness bug.
They have both now recovered and should go straight back into the starting XI along with on-loan goalkeeper Lee Nicholls, who together with forward Jake Robinson was ineligible for the first-round replay in West Yorkshire.
Midfielder Ben Harding, who has been an unused substitute recently, is ready to play again after almost a month out with an ankle injury.
Forward Louis Moult will serve the final game of his three-match ban while defender John Johnson will undergo a second knee operation on Saturday that will keep him out until January.
Wycombe's preparations have been given a boost with the return of Marvin McCoy (ankle and fibula) and Matt McClure (hamstring) to full training with Danny Foster (groin) set to follow suit.
Gareth Ainsworth has been without plenty of his first-team regulars in recent weeks but Gary Doherty (back), Matt Spring (calf), Jo Kuffour (ankle) and Anthony Stewart (thigh) also look set to return to training within the next 10 days.
Matt Bloomfield (groin) and Grant Basey (cruciate) continue their rehabilitation and are yet to return to training.