Gillingham boss Martin Allen will be without on-loan defender Tom Flanagan as his side look to extend their lead at the top of League Two.
Both sides enjoyed victories at the weekend, with Deon Burton scoring the Gills' winning goal against Morecambe in the third minute of added time for a 2-1 triumph.
With the exception of Flanagan, who has returned to MK Dons for treatment on a fractured metatarsal picked up in training, Allen has no major injury concerns as Gillingham look to continue their impressive run against the Grecians on home soil.
Table-toppers Gillingham, seven points clear of second-place Port Vale, have won their last four home meetings with City without conceding a goal and have only lost once at home all season.
Exeter boss Paul Tisdale has a number of players struggling for fitness.
Jamie Cureton's 13th goal of the season gave the Grecians a hard-fought 1-0 win over Bradford on Saturday and they now travel to face a Gillingham side that has lost just once at home.
"Our physio is going to have a tough couple of days because we have four or five that are packed in ice and bruised and battered," Tisdale told the Western Morning News.
"But if you want to be a successful team, you have to go to these places and meet the challenge. We have gone a long way to achieving some satisfactory points and it will be a big challenge at Gillingham."
The Grecians will have travelled over 1,000 miles in four days by the time they return from the Priestfield Stadium, a venue that has seen City lose their last four matches without scoring.