It's a hat-trick of victories in the space of a week for Villas-Boas's charges as they look to take up a march for third spot.
Dejagah tries to pull his pass from the left across the face of goal, only for Spurs last-line to clear the danger.
Cottagers earn themselves free-kick just over the halfway line but Riise's delivery into a packed box doesn't amount to much.
Four minutes of added time has been signalled; maybe just enough time for Defoe to complete his hat-trick?
A frustrated Sidwell gives away a silly free-kick in midfield for an poor tackle on Sandro.
Tottenham just passing the ball around at the back happy to wind down the clock.
Home supporters now have clearly seen enough as they make their out of the stadium in their droves.
Spurs composed at the back with the assurance of three away points in the bag.
Cottagers with a rare corner-kick which Duff whips in from the right, but Hughes' headed effort is off-target.
Fulham going backwards as they seem to now be struggling to pose a real attacking threat late on.
84 Dembele now comes off for Spurs for Thomas Carroll to make his cameo appearance in the top-flight.
Sandro tries to push up on the breakaway for Spurs but the Brazilian's pass up to Dempsey is intercepted.
Duff beats the offsides trap and feeds Rodallega in the box, but the substitute striker fluffs his headed chance.
Duff pulls his pass across the face of goal, but Vertonghen is well positioned to clear the danger.
Spurs have only kept one clean sheet in the league all season, so the hosts are still in with a chance of pulling one back before the end.
79 Petric departs for Rodallega to come on and may salvage a goal for the Cottagers.
There's surely no coming back for Fulham as Spurs look to have found another gear.
77 Two chances, two goals, as Defoe completes his brace with an early shot off Dempsey's pass to beat Schwarzer yet again.
Berbatov still trying to spark some magic for the hosts but even he is starting to look a little dejected.
Now the away fans are in full cry as their side looks to closing in on their fourth straight league win.
Hugo Rodallega looks to be warming up on the sidelines as Jol is forced to throw more attacking bodies forward.
It looks to be along way back for Jol's side considering how little they've created.
72 Defoe surely seals the victory for Spurs after he converts his one chance on goal for the match after a good pass into the box from Sigurdsson.
Long ball forward for Naughton to chase earns the visitors an attacking throw-in from the right.
Cottagers duplicate Spurs earlier efforts, with a poor decision from Dejagah killing off a decent attacking thrust.
Spurs on the attack but the wrong option-taking up front sees a good movement fizzles out.
The visitors having to try and attack from deep as the home side force them back with a high offensive line.
Spurs back in possession but don't look all that comfortable on the ball despite their slender advantage.
Berbatov, again, with a great touch out to the right for Duff, whose cross into the box sees Dejagah get his head to the ball but can't keep his effort down on target.
Riise steps for a long-range effort from a Cottagers free-kick, but the Norwegian fires wide of the mark.
John Arne Riise falls over at the near post trying to get his shot off.
Dempsey has shifted out wide in place Bale; lets see what the American can do from the change in position.
62 Frei comes off as veteran Damian Duff takes to the field, Sigurdsson also now officially on the park.
Gylfi Sigurdsson warming up on the sidelines as Bale receives treatment on the pitch.
Bale takes a shot from range that draws a stop from Schwarzer, but more worrying is the winger pulling up with what looks to be left hamstring strain.
Fulham really have to take the initiative now and force error form this Spurs team.
Berbatov, again, out on the right as he gets behind the defence but he fails to whip in a ball for Dejagah waiting in the area.
57 A bit of drama as Gallas goes into the book for illegally coming back on to the field after receiving treatment on the sidelines.
56 From out of nowhere, Sandro takes a speculative shot from some way out that swerves late to beat Schwarzer to give Spurs the lead.
Dempsey flies in with a headed chance but he couldn't get on the end of the cross in time.
Spurs on the back-foot as the Cottagers press up with earnest.
Berbatov with a decent run down the right flank, but his delivery into the area misses all Cottagers attackers going forward.
Mix-up between Diarra and Aaron Hughes at the back, but Dempsey's not quick enough to capitalise.
Spurs struggling to gain some ascendency since the restart.
Dempsey shrugs off the boos from the home fans to try and create something from midfield, only for the crowd to break out in cheers when he lose the ball.
Sidwell heads to ball forward for Dejagah to chase and the latter looked in with a fair chance only for the linesman's flag to go up for offsides.
Petric tees up Sidwell but the midfielder's shot is wide of goal when he really should've done better with the chance.
Frei with a lively run down the left flank as the Cottagers wideman maybe be looking to following through on Jol's instructions to lift the pace of their play.
Second half is underway!
i think you berbatov score first fulham win 3-0 ! coyw we need to show dempsey who the better club is!!! Jessica James
Hi Devin, going to be a good game today, can't understand why Walker isn't playing but going for 3-1 Spurs. Defoe with 2 Bale 1 and Berbatov 1. Come on you Spurs..... Neil Fox
A disappointing first half draws to a close with Villas-Boas probably the more frustrated of the two managers as they head down the tunnel.
The touchline official signals two minutes of added time as Spurs look to create something before the break.
Bale takes pot on goal from range, only to watch on as his strike sails wide.
Good piece of skill from Berbatov once again, but even he can't stop his pass going into touch.
Caulker sends up a long ball form the back in an almost Hail-Mary effort for a team-mates to latch on to it and dazzle, but no such luck.
Petric looks sharp in and around the area, so he fancies a shot from the edge of the box, but it's off target when he really should've done better.
The supporters have gone silent as the match staggers to a snail's pace.
Play has really slowed down as it looks as if Spurs are just going through the motions; the match right now is clearly there for the taking from Fulham's point of view.
Cottagers work there way forward and earn themselves their first corner of the match, but Dejagah's ball into the 18-yard area is poor.
Spurs push up in earnest but not's happening for them in the final third, Dembele losing the ball over the halfway line. He gets it back, only to lose it once more.
In a derby that promised so much has all been rather tepid with not much clear-cut chances on goal from either side.
Dejagah looks to have recovered well enough to return to the fray as Spurs work the ball around to once again find their rhythm.
Yet another delay in play as Dejagah receives some treatment to his back after taking a nasty fall.
Another long ball employed by the Cottagers, but Lloris plucks the ball out of the air with ease.
Good breakout from the back by the hosts with Dejagah looking to feed an overlapping Petric, but the pass is weak and the defence clears the danger.
Long ball up field for Berbatov, only for the striker to comes off second best in the air against Caulker.
Cottagers have forced their capital rivals back into their own half as the visitors gained the upperhand in the possession stakes.
Decent build up from Spurs, yet they're just to slow to get the ball up for Defoe.
29 Another early change in personnel, this time for Cottagers, Stephen Kelly coming on for Sascha Riether, whose favouring his knee.
Dembele tries to power his way through the midfield and into the box, only for the midfielder to be close down outside the area.
Berbatov, again, looks to feed his front-line with a crisp pass but the cover defence gets across to intercept.
Spurs attacking with a high line which may allow the Cottagers to get behind them on the counter.
Smart turn from Dempsey in the pocket sees the Spurs attacker let fly on goal again; off target but he's getting closer.
Petric with a great chance at the near post, but Lloris makes a good stop.
23 Bale rightly goes into the referee's book after the Spurs flyer hits the deck diving.
Spurs push up again with Bale trying to revive the momentum for the visiting outfit.
Ashkan Dejagah looks through on goal, but the linesman's flag comes up for offsides.
Dembele with a half-chance in the box, but fails to strike soon enough and Mark Schwarzer gets across to cover.
The play has all been bogged down in the middle of the field, although when the ball is fed to Berbatov the Bulgarian continues to look a class apart.
The pace of the match has definitely slowed since Dawson's departure; lets hope it picks up again soon.
Play resumes once again and it'll be interesting to see which of the two sides' attacking thrusts will have been affected most by the halt in proceedings.
16 Dawson makes a slow march off the park for William Gallas to take to the field in place of his captain.
Play is delayed as Spurs' medical staff attends to Dawson, the defender not at all looking comfortable.
Berbatov looking quality on attack with several superb touches, but it's Michael Dawson going down with what looks like a hamstring injury that's a worry for Spurs.
The game is settling into a nice ebb-and-flow with both sides looking good pushing up field.
Kerim Frei with a wasted chance on goal, his shot miles off target after another good ball into the danger area from Berbatov.
Dempsey, again, with a half-chance but the American's effort only hands the ball back to the home side for a goal-kick.
Mladen Petric tries to make something happen for the hosts from the halfway line, but only gives away a foul once Dembele stole the ball.
Bale with a poor attempt on goal from the set-piece, the Welshman shanking his effort well over the crossbar and almost out of the ground.
Mahamadou Diarra with a clumsy challenge on Bale earns the visitors a free-kick in a decent attacking area.
Vertonghen feeds Aaron Lennon out to the right with the England winger jinking his way around the area only to earn his side a corner kick.
Jan Vertonghen tries to carry the ball up strongly for Spurs, but the Belgian is driven into touch.
Clint Dempsey shows some great bit of skill to create some space for himself on the edge of the box, but much to the home fans enjoyment, the former Cottagers ace fires wide of goal.
Dimitar Berbatov with an excellent through ball for Steve Sidwell to chase into the box, but Hugo Lloris is quick off his mark to gather the ball.
Moussa Dembele and Gareth Bale pushing play over the halfway line for the visitors.
Spurs working the ball around at the back with Kyle Naughton, whose in for Kyle Walker on the right, getting a few early touches as he looks to get the feel of the match.
The match is underway!
Hello, gonna make this quick, really tough game, i like spurs, think they'll win 3-1. Cian Hughes
Feel free to e-mail your thoughts or predictions to firstname.lastname@example.org and we'll publish as many of them before - and during - the game as possible.
For the visitors, defender Steven Caulker is back in the picture after recovering from illness.
Brede Hangeland serves the last match of his three-game suspension. Alex Kacaniklic, Kieran Richardson and Bryan Ruiz all remain sidelined with hamstring injuries.
Fulham are rated at 15/8 to beat Tottenham today according to our friends at Sky Bet, with Spurs at 7/5 to win, while it is 12/5 for the match to end in a draw. Berbatov is 6/1 to score first, with Gareth Bale 2/1 to find the back of the net before the final whistle.
Meanwhile, Cottagers boss Martin Jol is still looking for a first win against the club he once managed, while the game will also see Dimitar Berbatov up against his former employers. The home side go into the match in 11th position. They managed a goalless draw with Chelsea last time out, but have not been in great form of late, having gone six games without a top-flight win.
Spurs go in search of a third straight Premier League victory as they travel across London to face their capital rivals. Their 2-1 win over Liverpool on Wednesday took Andre Villas-Boas's men up to fifth place on the standings.
Good afternoon, I'm Devin Hermanus and I'll be taking you through all the action as Fulham host Tottenham at Craven Cottage. Kick-off is scheduled for 1500 BST.