Lee Williamson could return to the starting line-up for the visit of the Lilywhites.
The midfielder shook off a calf problem to feature as a late substitute in the 2-2 draw at Tranmere last weekend.
Defenders Mustapha Dumbuya (knee) and Gabor Gyepes (heart palpitations) were also passed fit to face the leaders so Pompey caretaker boss Guy Whittingham has a full-strength squad to choose from.
Simon Eastwood is expected to keep his place in goal after an impressive display, meaning recent signing Phil Smith will be on the bench again.
Midfielder Darel Russell and forward Jake Jervis will be facing their former club.
The south coast club are without a win in nine matches but have drawn their last two having lost the previous seven.
Preston manager Graham Westley has hinted that Nicky Wroe and Lee Holmes may struggle to make the long trip south.
Although both players were able to play in last week's 3-1 defeat to Crewe, Westley revealed that the midfield pair are struggling.
Wroe has been missing training sessions after having a scan on his knee with Westley conceding his performances have dropped as a result.
He also announced Holmes is troubled with an illness which may result in him being unable to play the full 90 minutes at Fratton Park.
The visitors continue to be without defender Scott Laird (broken leg) and Keith Keane (knee) as the pair are long-term absentees.
Westley has been impressed by Portsmouth, despite their off-field problems.
"They've got some tremendous players there with great backgrounds and great qualities," he told his club's official website.
Striker Akpo Sodje will not be available after leaving with immediate effect after turning down an extension to his deal at Deepdale.
