Exeter manager Paul Tisdale could welcome back Tommy Doherty.
The experienced midfielder missed last weekend's 3-2 victory over Rochdale after picking up a hamstring injury against Rotherham the week before.
The manager will run the rule over Arron Davies ahead of kick-off after the winger aggravated his calf injury against Rochdale.
Speaking after the 3-2 win, Tisdale said: "I am hoping Arron Davies will be ok. He came on as a sub after not playing for six weeks and came off feeling his injury so we are going to have to be careful in the next couple of days.
"I hope we can have a clean bill of health and enjoy the lead up the game without worrying about late fitness tests and anything like that.
"Tommy (Doherty) was close to playing and had a fitness test on Thursday but it (the Rochdale game) was a week too soon for him."
Plymouth defender Durrell Berry will be available after serving his one-match suspension against York last week.
The 20-year-old missed the 2-0 win after he picked up two bookings in the Johnstone's Paint Trophy draw against Oxford.
His return could see veteran centre-back Darren Purse drop to the bench.
Argyle boss Carl Fletcher has no fresh injury or suspension concerns ahead of the game and could be tempted to stick with the same XI that recorded his side's first win in 10 games against the Minstermen.
Fletcher's men sit 20th in League Two, 13 places beneath Saturday's opponents who they have not beaten away from home in their two previous encounters since September 2001.