Jim Fenlon is suspended as AFC Wimbledon return to action following two postponements.
The defender was booked in the 1-0 defeat to Rotherham on December 15, taking his tally of cautions for the season to five, and he will serve a one-match ban.
Warren Cummings is the most likely candidate to deputise in Fenlon's absence.
Striker Byron Harrison, who has scored eight goals this term, is still struggling with the back injury which has kept him sidelined since December 8.
Charlton centre-back Yado Mambo will play the final match of his loan spell with the Dons. Assistant manager Neil Cox revealed the club would like to bring the 21-year-old back in January.
"He is going to go back to Charlton and we will have to find out the situation with him," Cox told Dons Player.
"We do not really know yet what they want to do with him, but we will just have to play it by ear."
Oxford will hand fitness tests to Liam Davis and Peter Leven.
The duo were both forced off with injuries during the 3-1 win away at Exeter on Boxing Day.
Davis came off just after the half-hour mark after suffering a hamstring injury while fellow midfielder Leven was forced off late on with a thigh problem.
Midfielder Simon Heslop is available again after completing his three-match suspension for a red card in the draw with Aldershot but Tony Capaldi serves a one-game ban after picking up a fifth booking of the season at Exeter.
Striker Josh Parker made his debut from the bench during the game and will be looking for another opportunity to impress.
The U's remain without striker Jon-Paul Pittman who is out for 11 weeks after undergoing surgery on a shoulder injury.