Plymouth boss Carl Fletcher will continue with 17-year-old striker Tyler Harvey.
Harvey marked his full debut for Argyle with a last-minute equaliser in the 1-1 draw with Torquay.
The result stretched the club's unbeaten run to four matches, following a third consecutive 1-1 draw, and the teenager is expected to be given another chance to impress.
Winger Paris Cowan-Hall was recalled to the starting line-up for the game after completing his recovery from a dead leg and should continue on the right-hand side.
On-loan midfielder Mark Molesley will be assessed ahead of kick-off after he was left out of the Boxing Day draw due to a hamstring problem.
Joe Lennox and Isaac Vassell's deals expire after the game, but Fletcher is looking into extending their stays in January.
Wycombe welcome back Matthew McClure and Matthew Spring.
Top scorer McClure served a one-match ban after his sending off for two yellow cards against Accrington, while midfielder Spring was sidelined for three games following his dismissal against Bradford in the Johnstone's Paint Trophy.
But player/manager Gareth Ainsworth remains without Joel Grant, who has one more game of his three-match suspension to serve, while Charles Dunne and Josh Scowen are doubts.
Defender Dunne was replaced at half time during the Boxing Day defeat at Cheltenham with a foot injury, while Scowen was also removed at the break after picking up a slight hamstring problem.
Defender Dave Winfield and forward Dean Morgan could both return after the pair missed the Boxing Day defeat with hamstring problems.
But Gary Doherty (back) is six weeks away from a return.