Goals from Johnnie Jackson and Scott Wagstaff made for a rare happy weekend at The Valley despite Nathan Eccleston's late consolation.
The Seasiders are looking for yet another boss after Michael Appleton quit to join Blackburn just 24 hours earlier, which meant assistant manager Steve Thompson took temporary charge, just as he had two months ago when Ian Holloway also jumped ship to a rival Championship side, Crystal Palace.
Kevin Phillips, who is also linked with the managers job, missed a gilt-edged chance to give the beleaguered visitors the lead after just two minutes.
The 39 year-old was unmarked, three yards out, when he met Nathan Delfouneso's cross but his header drifted back across goal, rolled against the far post and was hacked clear by Matt Taylor.
Instead Charlton recovered from their slow start and almost went ahead when Dale Stephens' corner found Taylor at the far post, only this time his header was nodded off the line by Delfouneso.
But Charlton did take the lead in the 23rd minute when Chris Solly's pass was deflected into the path of Jackson.
The midfielder's speculative effort from the edge of the box somehow bobbled its way past the diving Matt Gilks and into the bottom corner of the net.
Then in stoppage time Charlton grabbed their second when a slick move ended with Lawrie Wilson crossing to Yann Kermorgant.
His header was well saved by Gilks but the ball fell to the feet of Wagstaff, who rifled it back past the grounded keeper and into the net.
Blackpool spent the majority of the second half camped in Charlton's half, with Tom Ince's touch and pace impressive but his finishing wayward.
Phillips' race was run after 77 minutes and substitute Eccleston finally found the way to goal with an 18-yard drive in stoppage time, but Charlton were not to be denied only their fourth home win of the campaign.