Leyton Orient will be without Anthony Griffith and Kevin Lisbie.
The O's reached the Southern Area final of the Johnstone's Paint Trophy by beating Yeovil on Tuesday but the victory came at a cost after Griffith was sent off and Lisbie suffered a hamstring injury.
Midfielder Griffith will serve a two-match ban for his second red card of the season while striker Lisbie could be out for longer, with the O's waiting to discover the extent of the damage.
Leon McSweeney and Martin Rowlands were rested in midweek while Lee Cook came on as a late substitute, so they will be in contention to start.
Jamie Jones continues in goal with Ryan Allsop still out of favour after turning down a new contract.
Steve Davis could have a fully-fit squad to pick from as Crewe look to return to winning ways.
The manager's son, Harry, is a doubt due to illness but the defender has not been ruled out entirely.
Max Clayton and Ajay Leitch-Smith are battling for places in attack following Lauri Dalla Valle's return to Fulham at the end of his loan spell.
Brad Inman is set to start in midfield after the on-loan Newcastle youngster was rested among the substitutes in last weekend's 2-1 defeat at Stevenage, where he replaced goalscorer Chuks Aneke for the final 15 minutes.
Davis told Alex's official website: "I chose to rest Brad on Saturday because he was tired. He is not used to playing a succession of games in a short period of time.
"I just felt he needed a rest after the Carlisle game and I bought Chuks back in. Brad has had a rest and will come back into my thinking."