Chesterfield will be without Drew Talbot.
Talbot suffered a broken toe against Wycombe last weekend and the versatile 26-year-old is expected to be out for around a month.
Manager Paul Cook's squad has been hit by a virus, but the Liverpudlian stopped short of naming those players affected.
Brennan Dickenson has returned to Brighton following the end of his loan spell while fellow forwards Luis Boa Morte and Craig Westcarr left the club this week.
However, Cook hopes to re-sign MK Dons winger Jay O'Shea in time for Saturday's game.
O'Shea played the final match of his loan spell at Wycombe, scoring the Spireites' goal in their 2-1 defeat at Adams Park.
Cook is optimistic about his chances of bringing the Irishman back to the Proact Stadium on a permanent basis, describing the deal as "very close" to being completed.
Northampton boss Aidy Boothroyd is expected to name an unchanged side.
The Cobblers reported no fresh problems following the 3-1 home win over Fleetwood last weekend.
Jake Robinson sustained a large gash to a shin against the Cod Army but the forward has trained all week and will feature.
Long-term absentee David Artell is back in full training, along with fellow defender John Johnson, following an Achilles injury.
Boothroyd wants to give both players a run-out in a practice match before committing them to first-team action, though.
Northampton will take extra caution over the return of Johnson after he suffered a setback on his playing return in November. The right-back has since undergone a second knee operation.