Veteran midfielder Paul McKenna could make his Fleetwood debut.
McKenna was close to becoming former Preston team-mate Graham Alexander's fifth signing of the January transfer window on Friday.
Another ex-Preston midfielder, Barry Nicholson, is doubtful due to an ongoing back injury.
Striker Jon Parkin (hamstring) and defender Youl Mawene (broken foot) are not ready to return to first-team action despite resuming light training.
Parkin took part in a training game last weekend following a lengthy absence and told Fleetwood's official website: "It's been a bit of a grind. I managed to get back and then pulled up again in the first training session I took part in.
"I probably came back just a little bit too quickly. I just need to get fit and try and get in the team. Hopefully the goals will start coming from there."
Forward Andy Mangan (knee) is a long-term absentee.
Oxford are without the services of Liam Davis.
The left-back is expected to be out for a month due to a hamstring injury, with Luke O'Brien set to deputise.
O'Brien has signed a new deal this week which will keep the 24-year-old at the club until the end of the season after his short-term contract expired.
Ryan Clarke is still sidelined after undergoing operations on both shoulders with veteran goalkeeper Wayne Brown set to continue in goal.
Max Crocombe, who received a call-up to New Zealand's preliminary squad for the final stage of qualifying for the Under-20 World Cup this week, will offer cover for Brown from the bench.
Striker James Constable is pushing for a recall having served a four-match ban.
With last weekend's game against Rotherham postponed due to a frozen pitch, Chris Wilder's team have had a two-week break since their 2-1 victory at Capital One Cup finalists Bradford.