Plymouth boss John Sheridan has no fresh injury worries.
The Pilgrims welcome Leam Richardson's men knowing a win would draw them level on points with 19th-placed Stanley.
But Sheridan will be without strikers Nick Chadwick and Warren Feeney again. Chadwick will serve the second game of his six-match suspension for a red card against Port Vale while the Northern Ireland international is sidelined until the middle of March with an ankle injury.
And while the Argyle manager hopes to sign another forward, he currently has five inexperienced forwards at his disposal.
Loanees Ronan Murray and Gozie Ugwu, who could make his debut, may feature while Rhys Griffiths and youngsters Matt Lecointe and Tyler Harvey are also available.
Collectively the five strikers have made only 38 starts and 56 substitute appearances in the Football League, scoring a total of just 13 goals.
Accrington manager Leam Richardson has a virtually fully-fit squad to choose from.
Stanley secured an extension to Cameron Belford's loan from Bury this week and he will continue in goal with Ian Dunbavin (shoulder) out for the season.
Padraig Amond is ready to play following a recent groin injury absence and the striker wants Stanley to remain calm amid a run of one win in 10 league matches that leaves them precariously placed, four points above the relegation zone and three clear of their weekend opponents.
"The main thing is that we don't panic," he said. "We've beaten a lot of the big teams in the league this year so we've proved that we're capable of putting good performances together.
"We've been on a bad little run at the moment and it's important that we get out of it very quickly. But all it takes is one win and one good result and it can be a snowball effect, four or five wins together, and you're looking forward and not behind.
"We have our own targets, we know what we have to do, but we just have to kick on with each game and tick off the victories."