Crewe boss Steve Davis has a fully-fit squad to choose from.
Chuks Aneke returned to the club on loan from Arsenal until the end of the season on transfer deadline day and the attacking midfielder will look to add to six goals in 22 appearances for the Railwaymen this term.
Goalkeeper Alan Martin is ready to come back into the squad, in all likelihood on the bench, after recovering from a foot injury.
Utility man Matt Tootle is at Davis' disposal once more following a bout of illness.
Brad Inman is set to continue in midfield having extended his loan spell from Newcastle until the end of the campaign.
The Alex hope to return to winning ways against Brian Laws' struggling side having slipped eight points off the top six on the back of one point from their past three league matches.
Scunthorpe boss Brian Laws must decide whether to put fit-again midfielder Josh Walker straight into his starting line-up.
Walker, who has missed the last eight matches due to ankle ligament damage, was poised to return last week but succumbed to illness.
Laws must also decide whether to stick with Niall Canavan in central defence or recall David Mirfin, who returned to the substitutes' bench for the recent win at Colchester having missed the previous 10 games due to a knee injury.
Fellow defender Christian Ribeiro and midfielder Damien Mozika, who both remain sidelined with respective hamstring injuries, are hoping to return to contention in the next couple of weeks.
Scunthorpe, who have won one and drawn three of their last four league games, will be looking to avoid defeat in their bid to climb out of the relegation zone.