Antonio kick-started the Owls' revival by tapping in from close range after Derby had surged into a 2-0 lead.
The Rams opened the scoring in the 23rd minute when Jeff Hendrick finished a nice passing move by firing low past Chris Kirkland and Jamie Ward doubled the lead from the spot following Miguel Llera's foul soon after the restart.
But after Antonio's lifeline, Llera atoned for his misdemeanour by heading Wednesday level from good work by the goalscorer in the 56th minute.
Wednesday looked the most likely to go on and win it as debutant Connor Wickham was denied by a good save by Adam Legzdins, but they had to settle for a point which extends their unbeaten run to five npower Championship games.
Derby settled quickly and Ward, a former favourite across the city at Sheffield United, brought a low save out of Kirkland very early on, with the Owls keeper palming away a skidding effort well.
But Derby were not deterred and went ahead midway through the first half.
A fine passing move ended with Hendrick playing a one-two with Ward on the edge of the area and slamming a low shot into the corner, with Kirkland only able to get a hand on it.
Dave Jones' side were unable to show any of the fervour they displayed in despatching Brighton last week, though the home fans were given something to cheer as Friday's loan signing Wickham made his debut from the bench following an injury to Keiran Lee.
Top scorer Antonio tried to inspire his side with a speculative effort from distance, but Legzdins had no problems keeping it out as Derby saw out the first half with ease.
And three minutes after the restart they strengthened their position following Llera's foul on Ward and the striker dusted himself off and doubled the Rams' lead from the spot.
But that stirred the hosts into action and they got themselves back in it three minutes later when Antonio netted by reacting first to a loose ball from a corner.
The momentum of the game had totally shifted and the rampant hosts levelled in the 56th minute.
Antonio got the ball on the right, jinked away from his marker and sent a pinpoint cross for Llera to head home in front of the Kop.
Wednesday sensed a winner could be on the cards, with Wickham and David Prutton both going close but it ended all-square.