Accrington will be without midfielder Charlie Barnett.
Barnett begins a three-match ban following his red card for a rash challenge on Port Vale left-back Daniel Jones in the early stages of last weekend's 3-0 defeat.
Nicky Hunt has been given the all clear to resume training after suffering concussion against Plymouth a fortnight ago and could come into contention at right-back.
Goals have been hard to come by during Stanley's current slump and Leam Richardson's strugglers have failed to find the net in any of their last four outings.
It is a situation striker Padraig Amond might be unable to remedy despite resuming training following a troublesome groin complaint.
Bury loanee Mark Hughes made his Reds debut last weekend after joining on transfer deadline day and is expect to continue in the heart of defence.
Michael Timlin will miss Southend's trip having this week been ruled out for the rest of the season with a broken leg.
The midfielder sustained a displaced fracture of his tibia in the late stages of Tuesday night's 1-0 victory at Leyton Orient in the first leg of their Johnstone's Paint Trophy southern area final.
Midfielders Marc Laird and Michael Spillane both return to contention, however, having been cup-tied for the Trophy victory and their availability provides welcome relief for manager Paul Sturrock.
Leading scorer Gavin Tomlin has missed the last two matches with a thigh injury and is again set to miss out, while Sturrock will assess two unnamed defenders who are struggling with knocks.