That's it, Wigan win thanks to two goals from Arouna Kone and one from Maynor Figueroa. They coasted home after Pogrebnyak's red card on 55 minutes. Thanks for looking in.
Wigan are comfortably winding down the clock, and as it stands will move out of the drop zone with Villa losing at Arsenal.
McCleary fouls McArthur as three minutes are flashed up on the board - three too many probably for most Reading fans.
This will be a real blow for Reading, who had found an improved vein for form of late.
Wigan have a habit of climbing out of trouble late in the season, and this may kick start another great escape.
The third goal gave Wigan breathing space, and the sending off of Pogrebnyak made it all too easy.
Lots of blue seats can be seen as some home fans make for the exits.
Alcaraz replaces Boyce.
Kone goes for his hat trick, but his shot from 25 yards out, dead centre, shapes a long way wide of Federici's left post.
Another good save from Federici, Gomez stabbing the ball from the edge of the box and the Reading keeper diving to his right to push it away.
Some Reading fans are already drifting away with their side seemingly headed for defeat.
Figueroa forces a good save from Federici, lashing a shot from 25 yards with his left foot that the Aussie palms away high to his right.
Di Santo fires just over from a tight angle, and is then replaced by Jordi Gomez.
Ali Al Habsi has not had a serious save to make yet, which tells a story in itself.
With Villa drawing at Arsenal, Wigan will remain in the bottom three if it stays like this.
Le Fondre has hardly seen the ball since coming on, and a cross towards the substitute is easily cut out.
Wigan are looking very compsed, playing it out of defence and playing keep-ball.
Garath McCleary replaces Karacan.
The numerical advantage is really beginning to tell as Wigan repel a rare Reading attack.
Reading just cannot get out of their half as Wigan keep their foot on the gas.
Scharner and Boyce combine nicely after the Austrian is allowed to go on a long run. Di Santo is then inches away with a headed chance inside the six yard box.
Shaun Maloney's run into the box ends with his pass being cut out just in time - it's all Wigan at the moment.
Nice low cross from Beausejour is cut out by Reading as Wigan look to completely kill the game off.
Noel Hunt replaces Jimmy Kebe, so the Royals are back to two up front..
Emmerson Boyce is booked for a foul on Karacan - looks harsh, there was minimal contact, if any.
A weak shot from Leigertwood, 25 yards out, is easily blocked. Very comfortable for Wigan against 10 men.
Scharner is not the most popular player with the home fans, and they are booing him lustily when they get the chance.
Ian Harte has a free kick 30 yards out, but Morrison goes down in the box buit does not get a penalty after tangling with Scharner - a clash of heads.
Can Reading drag this one back? It will be one to remember if they do.
The striker lost the ball, lashed out in frustration, clipped Figueroa's ankles and saw red from Phil Dowd. Reading are in all sorts of trouble.
It gets worse for Reading - Pavel Pogrebnyak is dismissed for a foul on Figueroa.
Harte chips a free kick into the box, but Wigan clear. Home fans very unhappy, and rightly so.
That could have been 4-0 to Wigan, Di Santo inches away from touching in a Boyce cross inside the six yard box, having rampaged through the middle before laying the ball off to his right.
Reading need an almighty comeback, can they do it?
Cool finish from Figueroa, who slides the ball between Federici's legs after latching onto a fine ball through from Di Santo. Game over?
Reading 0-3 Wigan! Maynor Figueroa!
Pogrebnyak pulls it back to McAnuff, but his chipped cross is weak. Pogrebnyak passed up the chance to shoot.
So Reading got for two up front, and don't forget they came back from two down to West Brom for a stirring 3-2 win not too long ago.
Adam Le Fondre replaces Hope Akpan - can the super-sub save the day?
Glenn Howard is not getting too carried away: "Tense is not the word! Hope we hang on and climb out the relegation zone! We have a tendency to sit back when we're winning! I'm sticking by my 2-1 prediction come on you Latics!"
What a way to finish a half, Wigan are firmly in the driving seat. They started well, went off the boil but controlled the latter stages and scored twice in a couple of minutes. Cruel on Adam Federici, who made two fine saves earlier for Reading, who have been profligate with their own chances.
Great raking pass from Beausejour to Kone, who eludes the defence to delicately flick the ball over the diving Federici for a classy finish.
Reading 0-2 Wigan! Kone again!
Not spectacular, but how important might that be?
Figueroa flicked the ball goalwards, but it came off Kone's chest from a yard out, no chance for the keeper.
Reading 0-1 Wigan! Kone and Figueroa claim it!
Kone's cross from the right forces Kelly to head for a corner from under his own bar.
It's all Wigan pressure now following that chance for Kone, their best spell since the first five minutes.
Scharner wins a corner with a deflected shot, and Kone forces a fine save from Federici with a stabbed effort that the keeper palms away to his left.
Di Santo is the main Wigan threat, and Reading are hustling the striker at every opportunity.
That roused the Reading fans a bit, but it is still very quiet at the Madejski.
Scharner gets away with one, bundling over Pogrebnyak but not badly enough to give away a free kick according to the referee.
Maloney's free kick from the left lands on the six yard box, but there's no-one from Wigan to get on the end of it.
Leigertwood is booked for a crude challenge on Di Santo.
A little more possession from Wigan, but they have not tested Federici since Di Santo's early shot.
Di Santo sticks out a foot to the ball in the area, but had he left it Beausejour would have had a shooting chance. Frustration all round for Wigan.
The two midfields are cancelling each other out at the moment.
Akpan tries to rise to a cross inside Wigan's area, but he climbs all over McArthur and Phil Dowd blows for a free kick.
McArthur tries to find Kone, but his pass is far too heavy and allows Reading to clear at a goal kick.
Karacan scoops the ball a long way beyond Kebe as a Reading attack falters.
Wigan are playing the ball across their backline, but their fans are not so keen and urge them to get the ball downfield, which they do but they cannot force a chance onm the Reading goal.
Adrian Mariappa gets to the corner, but heads wide.
Better from Kebe, who feeds the ball across low from the right, but Scharner does superbly to get to the ball and deny Pogrebnyak in the six yard box.
Kebe looks to be going on another run on the right, but a terrible first touch sees the ball roll out past the bye-line.
Very risk-free fare so far, there is so much resting on this one today.
Karacan clumsily catches McArthur, who is sporting a facemask after getting crunched with a shoulder to the face at Old Trafford.
James McCarthy claims a penalty after tangling with Akpan, but Phil Dowd waves the protests away. Looks the right decision initially.
Reading very much on the front foot so far, Wigan have shown little attacking threat.
McArthur loses the ball in midfield, Akpan takes it up to the box but snatches at his shot and pulls it badly wide.
Both sides will want to make the most of dead-ball situations but Reading have wasted a free kick, not getting the ball above shoulder level and a Wigan head clears away.
Reading probing down both flanks through Kebe and McAnuff, but Boyce does well to deny the latter.
Jimmy Kebe drives a knock down just wide into the side netting, which makes half the ground very excited for a split-second.
Ian Harte puts in a teasing free kick, and Scharner does his defensive duty well, conceding a cornner with a back header.
Shaun Maloney's corner is met by Paul Scharner, but the defender cannot get downward pressure on it and the ball flies over the bar.
Pogrebnyak, ploughing a lone furrow up front, is getting a few long balls knocked up to him, but he's not able to keep hold of it as much as Reading need.
The PA announcer pleaded for Reading fans to "make some noise" pre-kick off but it is pretty quiet so far - very tense.
Pogrebnyak takes a tumble when tangling with Scharner, landing in the technical zone in front of McDermott - but there's no free kick to Reading's surprise.
Hope Akpan has a free header six yards out - and nods the ball a long way over, the recent signing could not get over the ball enough - good chance wasted.
Figueroa's long ball towards Beausejour is just too long and Federici has an easier task than his fine save earlier.
Di Santo gets away from Karacan, despite having his shirt pulled, shoots from outside the D and Federici makes a good save low to his right.
Jimmy Kebe breaks at pace and attacks down the right, but McArthur does well to get back, tracking the winger before blocking his through ball.
Di Santo has a shot from the edge of the box but a hooped shirt blocks his early effort.
The teams are out, Brian McDermott & Roberto Martinez have a friendly chat and we're all set!
Jordi Gomez, the hat trick hero in Wigan's 3-2 win over Reading in the autumn, is on the bench - will he fill the super-sub role for the Latics today?
Adrian Clay greets us from Goa, which I can assure you will be warmer than over here! "Come on Reading, we'll win 3-1 today because we know we must to stay up which we will."
The teams are back in the hutch as kick off approaches. Wigan fans may be pleased that Antolin Alcarz is back on the bench after missing six months with a groin problem.
Looks like Wigan are going for 3-5-2, while Reading may go with 4-5-1 - but as ever these things can change! What kind of formations and ploys are you looking for?
Glenn Howard is feeling the tension: "Massive game for both sides today... but I'm sticking with my boys, Wigan to win 2-1 fancy Kone and Maloney to score today. COME ON!!!" Drop me a line with your thoughts at email@example.com
Should Adam le Fondre come off the bench to score, he'll set a Premier League record for most goals by a sub in a season - he currently has six. That's David Fairclough-esque!
There's a smattering of people inside Reading's well-appointed ground as the teams go through their paces, but the rest must be getting a hot drink inside them - they'll need it..
Dylan Hughes has been in touch to say, "Biggest match of the season, but it is around the time Wigan start winning, so I'm gonna say 2-1 Wigan" What do you reckon? Email me at firstname.lastname@example.org, and let me know where in the world you are - there must be a few far-flung fans out there?
With just one defeat in their last five, Reading are the favourites, while Wigan have registered just one win in their last 10 Premier League outings. Many will fancy backing the draw at 12/5, but Reading HT/Draw FT is a tempting bet at 14/1. However, 40 per cent of the Royals' goals have come in the last 15 minutes of games, so a 0-0 as a half-time correct score may prove more sensible at 21/10. So, if you fancy a flutter, pop over to www.skybet.com
Wigan's win at Villa on 29 December is their only league win in the last 10 fixtures, and they are id dire need of three points. But, they've been here before haven't they?
Reading have thrown themselves a Premier League lifeline with an upturn in form since Christmas, although last ime out they lost at Stoke. But they have a good record of late at home, and it could be home form that decides their fate.
Did anyone say relegation six-pointer? That dread phrase is written all over this one, and ignoring last weekend's cup action, these two teams have been heading in opposite directions in the league of late.
Roberto Martinez has made seven changes to the side that eased to victory in the FA Cup at Huddersfield. Kone, McArthur, Figueroa and Scharner retain their places for this vital league fixture.
Three changes for Reading from the side that lost at Old Trafford, with Harte, Akpan and Kebe coming in. Suber sub Adam Le Fondre takes up his station on the bench having started on Monday.
What do you make of those lineups? Let me know your thoughts on this and anything else that takes your fancy by emailing email@example.com.
Reading team: Federici; Kelly, Harte, Mariappa, Morrison; Karacan, Leigertwood, Akpan, Kebe, McAnuff; Pogrebnyak. Subs: Taylor, Shorey, Pearce; McCleary, Robson-Kanu, Hunt, Le Fondre
Wigan team: Al Habsi, Kone, McCarthy, Caldwell (c), Di Santo, Maloney, McArthur, Boyce, Beausejour, Figueroa, Scharner. Subs:Robles, Stam, Alcaraz, Espinoza, Gomez, McManaman, Henriquez