Northampton defender Joe Widdowson is suspended for the visit of the Pilgrims.
Widdowson was booked for the 10th time this season during the 1-1 draw at AFC Wimbledon on Tuesday night and will begin a two-game ban.
With David Artell on the verge of a return to the squad, striker Alex Nicholls (broken leg) and defender Nana, who has been out since September 2011 with a knee problem, are the only other players unavailable to Town boss Aidy Boothroyd.
Artell recently suffered a setback in his recovery from the Achilles problem he sustained in October but the centre-back has been training this week and could come under consideration for a place in the squad on Saturday.
Nana has been training with the youth team but the right-back is nowhere near a first-team return and no date has been put on when he might be ready.
Plymouth striker Gozie Ugwu is available for their clash with the Cobblers after extending his loan stay from Reading.
The teenager's original one-month stay in Devon expired after Saturday's 1-0 defeat to Oxford but the two clubs have agreed a deal to see him stay at Home Park for another eight games.
Striker Nick Chadwick is still not available. The former Everton forward was handed a six-game ban after being sent off in the Pilgrims' 4-0 defeat to Port Vale on January 5 and he will serve the last of those matches on Saturday.
Fellow striker Warren Feeney is still sidelined while Andres Gurrieri is pushing for a start after a hat-trick in a Devon Bowl victory in midweek.
Argyle make the trip with only goal difference between themselves and the League Two relegation zone.