Northampton manager Aidy Boothroyd must decide whether to change a winning team.
Boothroyd expects to have the same players available after reporting no new problems following Saturday's 1-0 home victory over Plymouth.
One man pushing for a recall is Luke Guttridge. The midfielder has had to make do with a place on the bench in recent weeks since returning from a foot fracture.
"Luke is fine physically but I don't think he has been in the form he was in before he got injured," Boothroyd told the media ahead of Tuesday night's game.
"He is a terrific player and it shows you the quality of Lewis Hornby and his recent performances that I didn't think I could leave him out.
"Luke will get back in that team at some point because he is so determined or tenacious to do so.
"When you leave a player of Luke Guttridge's quality out it says to the rest of the squad that nobody is safe and that everybody must perform at all times."
Joe Widdowson will complete a two-match suspension while fellow defender David Artell is back to full fitness after an Achilles injury.
Bristol Rovers boss John Ward hopes to have striker Ryan Brunt back.
The January signing from Stoke missed the 1-1 draw with Morecambe on Saturday after suffering a knee injury against Rotherham.
But a scan showed no serious damage and Ward is hopeful the 19-year-old will be able to feature at Sixfields.
However, Ward is expected to be without Seanan Clucas after he left the Globe Arena pitch on a stretcher having sustained a heavy blow to the knee.
David Clarkson (ankle) and Fabian Broghammer (hamstring) are both likely to miss out against a Cobblers side who boast the second best home record in the division.
Having lost just twice in 2013, Rovers are now six points clear of the League Two relegation zone.