Yeovil's new signing Wes Fletcher could be handed a Glovers debut against Tranmere having made the temporary move from Burnley.
With striker James Hayter a doubt with a foot injury Fletcher, who signed a one-month loan deal on Thursday, is competing with fellow loanee Kwesi Appiah for a start alongside top scorer Paddy Madden.
Middlesbrough loanee Matt Dolan passed a fitness test to be named on the bench for the 2-0 defeat to Colchester on Tuesday and looks likely to be invloved again.
Left-back Nathan Ralph stood in for Jamie McAllister (ankle) and Gary Johnson will monitor his captain's fitness before the clash with Ronnie Moore's men.
Meanwhile Johnson also confirmed that striker Reuben Reid will continue his stay with League Two strugglers Plymouth for another month.
Tranmere will be without experienced duo Ian Goodison and Andy Robinson for their trip to the Glovers.
Centre-back Goodison came off with a groin strain during Tuesday night's 1-1 draw against Notts County, while playmaker Robinson sustained a hamstring injury.
They join on-loan Stoke striker Mamady Sidibe (hamstring) on the sidelines, while skipper James Wallace is out for the season after undergoing surgery on a medial knee ligament injury.
"Goody felt a bit of a pain in his groin on Tuesday and he'll miss Saturday," said Rovers boss Ronnie Moore on the club's official website. "He'll be a big miss for us.
"Andy Robinson will be out for two weeks and Mama will miss Saturday too. So you've got three lads missing with all that experience and you're going to miss those type of players.
"James had an operation on Tuesday so that's him finished for the season. Pieces of both ends of the ligament had come unattached so they've had to reconstruct that."