Chris Hackett will return to the starting line-up for Northampton.
Hackett has been rested in recent weeks due to niggling aches and pains and Town boss Aidy Boothroyd has admitted he has treated the midfielder as "a special case" for the long-term benefit of the team.
Boothroyd, who aside from Alex Nicholls (broken leg) has a fully-fit squad to choose from, believes Hackett's return to action will be like "unleashing a new player".
He told reporters ahead of the game: "I made the decision to leave Chris Hackett out last weekend.
"He is going to be very important for us in these last 10 games and I didn't want to risk losing him for a longer period by playing him when he wasn't quite 100% right.
"I've made him a bit of a special case but he's fit now and he's raring to go. He has no pain whatsoever so it will be like unleashing a new player against Accrington on Saturday."
Accrington manager Leam Richardson's list of absentees remains the same.
Tom Aldred is set to continue in defence with on-loan Bury centre-back Mark Hughes sidelined due to a calf injury that could keep him out for the rest of the season.
Striker Padraig Amond visited a specialist this week to get to the bottom of his groin/abductor complaint. The Irishman is closing in on a return but this weekend is likely to come too soon for him.
Goalkeeper Ian Dunbavin and forward Craig Lindfield are still out due to respective shoulder and ankle injuries.
Stanley edged out of the relegation zone thanks to four points from their previous two games, and skipper Luke Joyce hopes they can capitalise on any after effects Northampton might be feeling from a loss to Exeter last time out.
"We need to go there and start well," he said. "They'll be disappointed with the result they had at the weekend and if we can play on it, any nerves and disappointment they've got from it, then we'll make the most of it."